RGS5 (regulator of G protein signaling 5)

2007-04-01  

Identity

HGNC
RGS5
LOCATION
1q23.3
LOCUSID
8490
ALIAS
MST092,MST106,MST129,MSTP032,MSTP092,MSTP106,MSTP129
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8490
MIM: 603276
HGNC: 10001
Ensembl: ENSG00000232995

Variants:

dbSNP: 8490
ClinVar: 8490
TCGA: ENSG00000232995
COSMIC: RGS5

RNA/Proteins

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD25069475
PA130232992bevacizumabChemicalClinicalAnnotationassociatedPD25069475
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD25069475
PA450085irinotecanChemicalClinicalAnnotationassociatedPD25069475
PA450198leucovorinChemicalClinicalAnnotationassociatedPD25069475

References

Pubmed IDYearTitleCitations
194880442009Genome-wide association study of bipolar disorder in European American and African American individuals.162
154590062005Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172203562007N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.48
206439372010Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload.45
147554432004Confirming RGS4 as a susceptibility gene for schizophrenia.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23

Citation

Dessen P

RGS5 (regulator of G protein signaling 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46825/rgs5