Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RGS6 (regulator of G protein signaling 6)

Identity

Alias_namesregulator of G-protein signalling 6
regulator of G-protein signaling 6
Other aliasGAP
HA117
S914
HGNC (Hugo) RGS6
LocusID (NCBI) 9628
Atlas_Id 47027
Location 14q24.2  [Link to chromosome band 14q24]
Location_base_pair Starts at 71933038 and ends at 72566530 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BBOF1 (14q24.3) / RGS6 (14q24.2)CCDC176 () / RGS6 (14q24.2)CDC42BPB (14q32.32) / RGS6 (14q24.2)
RGS6 (14q24.2) / NPAS3 (14q13.1)RGS6 (14q24.2) / RGS6 (14q24.2)C14orf45 RGS6 14q24.2
CDC42BPB 14q32.32 / RGS6 14q24.2RGS6 14q24.2 / NPAS3 14q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;14)(q13;q24) RGS6/NPAS3
t(14;14)(q24;q32) CDC42BPB/RGS6

External links

Nomenclature
HGNC (Hugo)RGS6   10002
Cards
Entrez_Gene (NCBI)RGS6  9628  regulator of G protein signaling 6
AliasesGAP; HA117; S914
GeneCards (Weizmann)RGS6
Ensembl hg19 (Hinxton)ENSG00000182732 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182732 [Gene_View]  ENSG00000182732 [Sequence]  chr14:71933038-72566530 [Contig_View]  RGS6 [Vega]
ICGC DataPortalENSG00000182732
TCGA cBioPortalRGS6
AceView (NCBI)RGS6
Genatlas (Paris)RGS6
WikiGenes9628
SOURCE (Princeton)RGS6
Genetics Home Reference (NIH)RGS6
Genomic and cartography
GoldenPath hg38 (UCSC)RGS6  -     chr14:71933038-72566530 +  14q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RGS6  -     14q24.2   [Description]    (hg19-Feb_2009)
GoldenPathRGS6 - 14q24.2 [CytoView hg19]  RGS6 - 14q24.2 [CytoView hg38]
ImmunoBaseENSG00000182732
Mapping of homologs : NCBIRGS6 [Mapview hg19]  RGS6 [Mapview hg38]
OMIM603894   
Gene and transcription
Genbank (Entrez)AB209462 AF073920 AF073921 AF107619 AF107620
RefSeq transcript (Entrez)NM_001204416 NM_001204417 NM_001204418 NM_001204419 NM_001204420 NM_001204421 NM_001204422 NM_001204423 NM_001204424 NM_001370270 NM_001370271 NM_001370272 NM_001370273 NM_001370274 NM_001370275 NM_001370276 NM_001370277 NM_001370278 NM_001370279 NM_001370280 NM_001370281 NM_001370282 NM_001370283 NM_001370284 NM_001370286 NM_001370287 NM_001370288 NM_001370289 NM_001370290 NM_001370291 NM_001370292 NM_001370293 NM_001370294 NM_004296
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RGS6
Cluster EST : UnigeneHs.552227 [ NCBI ]
CGAP (NCI)Hs.552227
Alternative Splicing GalleryENSG00000182732
Gene ExpressionRGS6 [ NCBI-GEO ]   RGS6 [ EBI - ARRAY_EXPRESS ]   RGS6 [ SEEK ]   RGS6 [ MEM ]
Gene Expression Viewer (FireBrowse)RGS6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9628
GTEX Portal (Tissue expression)RGS6
Human Protein AtlasENSG00000182732-RGS6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49758   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49758  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49758
Splice isoforms : SwissVarP49758
PhosPhoSitePlusP49758
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    RGS (PS50132)   
Domains : Interpro (EBI)DEP_dom    G-protein_gamma-like_dom    GGL_sf    RGS    RGS6_RGS    RGS_sf    RGS_subdom1/3    WH-like_DNA-bd_sf    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)DEP (PF00610)    G-gamma (PF00631)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00610    pfam00631    pfam00615   
Domain families : Smart (EMBL)DEP (SM00049)  GGL (SM00224)  RGS (SM00315)  
Conserved Domain (NCBI)RGS6
DMDM Disease mutations9628
Blocks (Seattle)RGS6
PDB (RSDB)2ES0   
PDB Europe2ES0   
PDB (PDBSum)2ES0   
PDB (IMB)2ES0   
Structural Biology KnowledgeBase2ES0   
SCOP (Structural Classification of Proteins)2ES0   
CATH (Classification of proteins structures)2ES0   
SuperfamilyP49758
Human Protein Atlas [tissue]ENSG00000182732-RGS6 [tissue]
Peptide AtlasP49758
IPIIPI00218951   IPI00218952   IPI00942997   IPI00216322   IPI00216323   IPI00216324   IPI00216325   IPI00216326   IPI00216327   IPI00216328   IPI00216329   IPI00921926   IPI00902901   IPI01011959   IPI01024749   IPI01011552   IPI00939274   IPI00980406   
Protein Interaction databases
DIP (DOE-UCLA)P49758
IntAct (EBI)P49758
FunCoupENSG00000182732
BioGRIDRGS6
STRING (EMBL)RGS6
ZODIACRGS6
Ontologies - Pathways
QuickGOP49758
Ontology : AmiGOGTPase activity  GTPase activator activity  protein binding  nucleus  cytosol  plasma membrane  G protein-coupled receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  negative regulation of signal transduction  extrinsic component of membrane  intracellular signal transduction  positive regulation of GTPase activity  
Ontology : EGO-EBIGTPase activity  GTPase activator activity  protein binding  nucleus  cytosol  plasma membrane  G protein-coupled receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  negative regulation of signal transduction  extrinsic component of membrane  intracellular signal transduction  positive regulation of GTPase activity  
NDEx NetworkRGS6
Atlas of Cancer Signalling NetworkRGS6
Wikipedia pathwaysRGS6
Orthology - Evolution
OrthoDB9628
GeneTree (enSembl)ENSG00000182732
Phylogenetic Trees/Animal Genes : TreeFamRGS6
HOGENOMP49758
Homologs : HomoloGeneRGS6
Homology/Alignments : Family Browser (UCSC)RGS6
Gene fusions - Rearrangements
Fusion : MitelmanCCDC176/RGS6 [14q24.3/14q24.2]  [t(14;14)(q24;q24)]  
Fusion : MitelmanCDC42BPB/RGS6 [14q32.32/14q24.2]  [t(14;14)(q24;q32)]  
Fusion : MitelmanRGS6/NPAS3 [14q24.2/14q13.1]  [t(14;14)(q13;q24)]  
Fusion PortalC14orf45 RGS6 14q24.2 BRCA
Fusion PortalCDC42BPB 14q32.32 RGS6 14q24.2 SKCM
Fusion PortalRGS6 14q24.2 NPAS3 14q13.1 LGG
Fusion : QuiverRGS6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRGS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RGS6
dbVarRGS6
ClinVarRGS6
1000_GenomesRGS6 
Exome Variant ServerRGS6
ExAC (Exome Aggregation Consortium)ENSG00000182732
GNOMAD BrowserENSG00000182732
Varsome BrowserRGS6
Genetic variants : HAPMAP9628
Genomic Variants (DGV)RGS6 [DGVbeta]
DECIPHERRGS6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRGS6 
Mutations
ICGC Data PortalRGS6 
TCGA Data PortalRGS6 
Broad Tumor PortalRGS6
OASIS PortalRGS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRGS6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRGS6
Mutations and Diseases : HGMDRGS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RGS6
DgiDB (Drug Gene Interaction Database)RGS6
DoCM (Curated mutations)RGS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RGS6 (select a term)
intoGenRGS6
Cancer3DRGS6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603894   
Orphanet
DisGeNETRGS6
MedgenRGS6
Genetic Testing Registry RGS6
NextProtP49758 [Medical]
TSGene9628
GENETestsRGS6
Target ValidationRGS6
Huge Navigator RGS6 [HugePedia]
snp3D : Map Gene to Disease9628
BioCentury BCIQRGS6
ClinGenRGS6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9628
Chemical/Pharm GKB GenePA34377
Clinical trialRGS6
Miscellaneous
canSAR (ICR)RGS6 (select the gene name)
DataMed IndexRGS6
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRGS6
EVEXRGS6
GoPubMedRGS6
iHOPRGS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:04:51 CET 2019
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