RHAG (Rh associated glycoprotein)

2014-11-01 Affiliation

Identity

HGNC

RHAG

LOCATION

6p12.3

LOCUSID

6005

ALIAS

CD241,OHS,OHST,RH2,RH50A,RHNR,Rh50,Rh50GP,SLC42A1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6005
MIM: 180297
HGNC: 10006
Ensembl: ENSG00000112077

Variants:

dbSNP: 6005
ClinVar: 6005
TCGA: ENSG00000112077
COSMIC: RHAG

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112077	ENST00000229810	A0A0A0MQS8
ENSG00000112077	ENST00000371175	Q02094
ENSG00000112077	ENST00000618248	A0A087WZZ4
ENSG00000112077	ENST00000646272	A0A2R8YEH1
ENSG00000112077	ENST00000646939	Q02094
ENSG00000112077	ENST00000646963	Q9UHG9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Rhesus glycoproteins mediate ammonium transport.	REACTOME	R-HSA-444411
Metabolism	REACTOME	R-HSA-1430728
O2/CO2 exchange in erythrocytes	REACTOME	R-HSA-1480926
Erythrocytes take up carbon dioxide and release oxygen	REACTOME	R-HSA-1237044
Erythrocytes take up oxygen and release carbon dioxide	REACTOME	R-HSA-1247673

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19273840	2009	Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG.	93
15572441	2004	Human Rhesus-associated glycoprotein mediates facilitated transport of NH(3) into red blood cells.	50
17712059	2008	RhAG protein of the Rhesus complex is a CO2 channel in the human red cell membrane.	48
11861637	2002	Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter.	41
18931342	2009	The monovalent cation leak in overhydrated stomatocytic red blood cells results from amino acid substitutions in the Rh-associated glycoprotein.	28
14966114	2004	Mechanism of genetic complementation of ammonium transport in yeast by human erythrocyte Rh-associated glycoprotein.	20
24077989	2013	Relative CO₂/NH₃ permeabilities of human RhAG, RhBG and RhCG.	12
26354748	2015	Mechanisms of ammonia and ammonium transport by rhesus-associated glycoproteins.	12
16564724	2006	The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins.	11
16574458	2006	Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis.	11

Citation

Dessen P

RHAG (Rh associated glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72622/rhag