Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 79651
MIM: 614404
HGNC: 20788
Ensembl: ENSG00000129667
Variants:
dbSNP: 79651
ClinVar: 79651
TCGA: ENSG00000129667
COSMIC: RHBDF2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21622719 | |
| PA449599 | fentanyl | Chemical | ClinicalAnnotation | associated | PD | 21622719 | |
| PA450550 | morphine | Chemical | ClinicalAnnotation | associated | PD | 21622719 | |
| PA450741 | oxycodone | Chemical | ClinicalAnnotation | associated | PD | 21622719 | |
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | PD | 21622719 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38183983 | 2024 | Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway. | 2 |
| 38570362 | 2024 | iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I. | 0 |
| 38781971 | 2024 | Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals. | 0 |
| 38183983 | 2024 | Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway. | 2 |
| 38570362 | 2024 | iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I. | 0 |
| 38781971 | 2024 | Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals. | 0 |
| 36943228 | 2023 | RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker. | 0 |
| 37271223 | 2023 | EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells. | 2 |
| 37544908 | 2023 | Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2. | 2 |
| 36943228 | 2023 | RHBDF2 is correlated with immune infiltrates in hepatocellular carcinoma and may have potential as a biomarker. | 0 |
| 37271223 | 2023 | EGFR stimulation enables IL-6 trans-signalling via iRhom2-dependent ADAM17 activation in mammary epithelial cells. | 2 |
| 37544908 | 2023 | Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S-Palmitoylated IRHOM2. | 2 |
| 35585977 | 2022 | Attenuation of Excess TNF-α Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking. | 3 |
| 35887045 | 2022 | Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress. | 0 |
| 35971826 | 2022 | iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells. | 7 |
Citation
Dessen P
RHBDF2 (rhomboid 5 homolog 2)
Atlas Genet Cytogenet Oncol Haematol. 2012-08-01
Online version: http://atlasgeneticsoncology.org/gene/52834/rhbdf2
