RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1)

2012-09-01  

Identity

HGNC
LOCATION
12p13.33
LOCUSID
ALIAS
C12orf32,HKMT1188,RHINO

Other Information

Locus ID:

NCBI: 83695
MIM: 614085
HGNC: 28206
Ensembl: ENSG00000171792

Variants:

dbSNP: 83695
ClinVar: 83695
TCGA: ENSG00000171792
COSMIC: RHNO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171792ENST00000366285F5H580
ENSG00000171792ENST00000461997Q9BSD3
ENSG00000171792ENST00000489288Q9BSD3
ENSG00000171792ENST00000535978F5H795
ENSG00000171792ENST00000538636F5H7S2
ENSG00000171792ENST00000538700F5H0U1
ENSG00000171792ENST00000618250Q9BSD3

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

References

Pubmed IDYearTitleCitations
383547792024Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO.0
383547792024Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO.0
373643912023RHNO1 disruption inhibits cell proliferation and induces mitochondrial apoptosis via PI3K/Akt pathway in hepatocellular carcinoma.0
374406122023RHINO directs MMEJ to repair DNA breaks in mitosis.21
373643912023RHNO1 disruption inhibits cell proliferation and induces mitochondrial apoptosis via PI3K/Akt pathway in hepatocellular carcinoma.0
374406122023RHINO directs MMEJ to repair DNA breaks in mitosis.21
338905742021Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer.12
338905742021Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer.12
256025202015RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.25
256025202015RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.25
245627722014Evaluation of the RHINO gene for breast cancer predisposition in Finnish breast cancer families.1
245627722014Evaluation of the RHINO gene for breast cancer predisposition in Finnish breast cancer families.1
216596032011A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.125
216596032011A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.125
208117082010Involvement of C12orf32 overexpression in breast carcinogenesis.10

Citation

Dessen P

RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52867/rhno1