RHOD (ras homolog family member D)

2008-09-01  

Identity

HGNC
LOCATION
11q13.2
LOCUSID
ALIAS
ARHD,RHOHP1,RHOM,Rho
FUSION GENES

Other Information

Locus ID:

NCBI: 29984
MIM: 605781
HGNC: 670
Ensembl: ENSG00000173156

Variants:

dbSNP: 29984
ClinVar: 29984
TCGA: ENSG00000173156
COSMIC: RHOD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173156ENST00000308831O00212
ENSG00000173156ENST00000532559E9PIG5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220

References

Pubmed IDYearTitleCitations
191600182009Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.212
184079992008A p120 catenin isoform switch affects Rho activity, induces tumor cell invasion, and predicts metastatic disease.77
166516392006Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch.64
170565912006The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.62
179165602007Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.51
188295322008Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.37
186486642008Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.24
206309392010Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.16
230872062012RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules.16
247063582014Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex.13

Citation

Dessen P

RHOD (ras homolog family member D)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50349/rhod