RHOF (ras homolog family member F, filopodia associated)

2014-11-01  

Identity

HGNC
RHOF
LOCATION
12q24.31
LOCUSID
54509
ALIAS
ARHF,RIF

Other Information

Locus ID:

NCBI: 54509
MIM: 618867
HGNC: 15703
Ensembl: ENSG00000139725

Variants:

dbSNP: 54509
ClinVar: 54509
TCGA: ENSG00000139725
COSMIC: RHOF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139725ENST00000267205Q9HBH0
ENSG00000139725ENST00000535560F5GXB1
ENSG00000139725ENST00000537171Q9HBH0
ENSG00000139725ENST00000537265V9GY67
ENSG00000139725ENST00000541657V9GYB3
ENSG00000139725ENST00000546227V9GYQ1

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
110843412000The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements.26
202338482010The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells.16
222519712012The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.14
186637542008Array-based comparative genomic hybridization in early-stage mycosis fungoides: recurrent deletion of tumor suppressor genes BCL7A, SMAC/DIABLO, and RHOF.12
222607032012The small Rho GTPase Rif and actin cytoskeletal remodelling.11
256684922015The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction.3

Citation

Dessen P

RHOF (ras homolog family member F, filopodia associated)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72631/rhof