RHOQ (ras homolog family member Q)

2003-02-01  

Identity

HGNC
LOCATION
2p21
LOCUSID
ALIAS
ARHQ,HEL-S-42,RASL7A,TC10,TC10A
FUSION GENES

Other Information

Locus ID:

NCBI: 23433
MIM: 605857
HGNC: 17736
Ensembl: ENSG00000119729

Variants:

dbSNP: 23433
ClinVar: 23433
TCGA: ENSG00000119729
COSMIC: RHOQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119729ENST00000238738P17081
ENSG00000119729ENST00000238738V9HWD0
ENSG00000119729ENST00000432183F8WET9
ENSG00000119729ENST00000473428H0YB93
ENSG00000119729ENST00000482449E5RFZ3
ENSG00000119729ENST00000489471H0YB40

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases regulate CFTR traffickingREACTOMER-HSA-5627083
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148

References

Pubmed IDYearTitleCitations
126870042003The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.132
162467322005An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.50
155468642005Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10.32
186604892008Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.26
204160772010Identification of type 2 diabetes-associated combination of SNPs using support vector machine.26
246632142014RNA editing in RHOQ promotes invasion potential in colorectal cancer.26
169501302006GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.22
242239962013GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70.19
242979112013Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.16
192583912009TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.12

Citation

Dessen P

RHOQ (ras homolog family member Q)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42113/rhoq