RHOT1 (ras homolog family member T1)

2003-05-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
ARHT1,MIRO-1,MIRO1
FUSION GENES

Other Information

Locus ID:

NCBI: 55288
MIM: 613888
HGNC: 21168
Ensembl: ENSG00000126858

Variants:

dbSNP: 55288
ClinVar: 55288
TCGA: ENSG00000126858
COSMIC: RHOT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126858ENST00000333942Q8IXI2
ENSG00000126858ENST00000354266H7BXZ6
ENSG00000126858ENST00000358365Q8IXI2
ENSG00000126858ENST00000394692Q8IXI2
ENSG00000126858ENST00000545287Q8IXI2
ENSG00000126858ENST00000578205J3KSR5
ENSG00000126858ENST00000580392J3QLG2
ENSG00000126858ENST00000581031Q8IXI2
ENSG00000126858ENST00000581094Q8IXI2
ENSG00000126858ENST00000581148K7EP86
ENSG00000126858ENST00000582602K7EIQ7
ENSG00000126858ENST00000583994J3KSR5
ENSG00000126858ENST00000584692J3QSG2
ENSG00000126858ENST00000584852J3KRG7
ENSG00000126858ENST00000646284A0A2R8Y4I2
ENSG00000126858ENST00000652713A0A494C061

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220788852011PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.411
190981002008Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.204
166305622006The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.148
276182162016Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.94
191032912009GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
246714172014Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.59
244929632014Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity.48
240923292014DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking.35
242562482013Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins.31

Citation

Dessen P

RHOT1 (ras homolog family member T1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42114/rhot1