RIC3 (RIC3 acetylcholine receptor chaperone)

2014-11-01  

Identity

HGNC
RIC3
LOCATION
11p15.4
LOCUSID
79608
ALIAS
AYST720,PRO1385
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79608
MIM: 610509
HGNC: 30338
Ensembl: ENSG00000166405

Variants:

dbSNP: 79608
ClinVar: 79608
TCGA: ENSG00000166405
COSMIC: RIC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166405ENST00000309737Q7Z5B4
ENSG00000166405ENST00000335425Q7Z5B4
ENSG00000166405ENST00000335425A0A0S2Z6D3
ENSG00000166405ENST00000343202Q7Z5B4
ENSG00000166405ENST00000343202A0A0S2Z607
ENSG00000166405ENST00000419822Q7Z5B4
ENSG00000166405ENST00000425599Q7Z5B4
ENSG00000166405ENST00000526962E9PNI0
ENSG00000166405ENST00000528463E9PKX8
ENSG00000166405ENST00000531450E9PK46

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
128216692003Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression.64
155047252005Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells.49
182460962008RIC-3: a nicotinic acetylcholine receptor chaperone.46
159279542005Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors.34
182085442008Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues.19
158092992005Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3.18
176092002007Differential subcellular localization of RIC-3 isoforms and their role in determining 5-HT3 receptor composition.16
184710732008Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.16
181794772008Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression.14

Citation

Dessen P

RIC3 (RIC3 acetylcholine receptor chaperone)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72639/ric3