RIC8B (RIC8 guanine nucleotide exchange factor B)

2014-11-01  

Identity

HGNC
RIC8B
LOCATION
12q23.3
LOCUSID
55188
ALIAS
RIC8,hSyn
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55188
MIM: 609147
HGNC: 25555
Ensembl: ENSG00000111785

Variants:

dbSNP: 55188
ClinVar: 55188
TCGA: ENSG00000111785
COSMIC: RIC8B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111785ENST00000355478Q9NVN3
ENSG00000111785ENST00000392837B7WPL0
ENSG00000111785ENST00000392839Q9NVN3
ENSG00000111785ENST00000462949Q9NVN3
ENSG00000111785ENST00000462949A0A024RBG9
ENSG00000111785ENST00000470960Q9NVN3
ENSG00000111785ENST00000546449J3QRA4
ENSG00000111785ENST00000548914H0YHS3
ENSG00000111785ENST00000549643F8VR30
ENSG00000111785ENST00000550215F8VSN5
ENSG00000111785ENST00000552619F8VY51

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
126526422003Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol.24
201339392010Ric-8B stabilizes the alpha subunit of stimulatory G protein by inhibiting its ubiquitination.22
269661862016ARMS/Kidins220 and synembryn-B levels regulate NGF-mediated secretion.3
267294112016The CREB Transcription Factor Controls Transcriptional Activity of the Human RIC8B Gene.0

Citation

Dessen P

RIC8B (RIC8 guanine nucleotide exchange factor B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72641/ric8b