RIOK2 (RIO kinase 2)

2006-10-01  

Identity

HGNC
LOCATION
5q15
LOCUSID
ALIAS
RIO2

Other Information

Locus ID:

NCBI: 55781
MIM: 617754
HGNC: 18999
Ensembl: ENSG00000058729

Variants:

dbSNP: 55781
ClinVar: 55781
TCGA: ENSG00000058729
COSMIC: RIOK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000058729ENST00000283109Q9BVS4
ENSG00000058729ENST00000508447Q9BVS4
ENSG00000058729ENST00000510384D6RB96
ENSG00000058729ENST00000511012H0Y919
ENSG00000058729ENST00000511293H0Y8R4

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
349379192022Identification of RIOK2 as a master regulator of human blood cell development.9
366616802022RIOK2 Contributes to Cell Growth and Protein Synthesis in Human Oral Squamous Cell Carcinoma.1
349379192022Identification of RIOK2 as a master regulator of human blood cell development.9
366616802022RIOK2 Contributes to Cell Growth and Protein Synthesis in Human Oral Squamous Cell Carcinoma.1
336285872021BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas.10
341258332021RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.7
336285872021BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas.10
341258332021RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit.7
321257672020RIOK2 is negatively regulated by miR-4744 and promotes glioma cell migration/invasion through epithelial-mesenchymal transition.12
321257672020RIOK2 is negatively regulated by miR-4744 and promotes glioma cell migration/invasion through epithelial-mesenchymal transition.12
313909392019In vitro dimerization of human RIO2 kinase.4
313909392019In vitro dimerization of human RIO2 kinase.4
297494342018miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1.16
297494342018miR‑145 inhibits human non‑small-cell lung cancer growth by dual-targeting RIOK2 and NOB1.16
258918992015Discovery of selective RIO2 kinase small molecule ligand.6

Citation

Dessen P

RIOK2 (RIO kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43471/riok2