RIPK4 (receptor interacting serine/threonine kinase 4)

2007-07-01  

Identity

HGNC
RIPK4
LOCATION
21q22.3
LOCUSID
54101
ALIAS
ANKK2,ANKRD3,CHANDS,DIK,NKRD3,PKK,PPS2,RIP4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54101
MIM: 605706
HGNC: 496
Ensembl: ENSG00000183421

Variants:

dbSNP: 54101
ClinVar: 54101
TCGA: ENSG00000183421
COSMIC: RIPK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183421ENST00000332512P57078
ENSG00000183421ENST00000352483P57078

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
233715532013Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.34
251345342014Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women.31
221974882012Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.23
170392402007Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair.21
126769342003Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner.14
198187682010RIP4 is a target of multiple signal transduction pathways in keratinocytes: implications for epidermal differentiation and cutaneous wound repair.14
252465262014Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation.14
180251522008Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells.13
244130832015Retroviral insertional mutagenesis in telomerase-immortalized hepatocytes identifies RIPK4 as novel tumor suppressor in human hepatocarcinogenesis.13

Citation

Dessen P

RIPK4 (receptor interacting serine/threonine kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47632/ripk4