RLIM (ring finger protein, LIM domain interacting)

2003-06-01  

Identity

HGNC
RLIM
LOCATION
Xq13.2
LOCUSID
51132
ALIAS
MRX61,NY-REN-43,RNF12,TOKAS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51132
MIM: 300379
HGNC: 13429
Ensembl: ENSG00000131263

Variants:

dbSNP: 51132
ClinVar: 51132
TCGA: ENSG00000131263
COSMIC: RLIM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131263ENST00000332687Q9NVW2
ENSG00000131263ENST00000349225Q9NVW2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199453822009RNF12 is an X-Encoded dose-dependent activator of X chromosome inactivation.82
191642952009Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.19
128741352003Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions.17
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
219459332011RLIM interacts with Smurf2 and promotes TGF-β induced U2OS cell migration.8
239042712013Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling.8
246860882014Rlim, an E3 ubiquitin ligase, influences the stability of Stathmin protein in human osteosarcoma cells.7
269264242016RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction.6
257354842015Syndromic X-linked intellectual disability segregating with a missense variant in RLIM.4
297424182018RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.4

Citation

Dessen P

RLIM (ring finger protein, LIM domain interacting)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42127/rlim