RN7SK (RNA component of 7SK nuclear ribonucleoprotein)

2017-05-01  

Identity

HGNC
LOCATION
6p12.2
LOCUSID
ALIAS
7SK

Other Information

Locus ID:

NCBI: 125050
MIM: 606515
HGNC: 10037
Ensembl: ENSG00000202198

Variants:

dbSNP: 125050
ClinVar: 125050
TCGA: ENSG00000202198
COSMIC: RN7SK

RNA/Proteins

References

Pubmed IDYearTitleCitations
204719492010HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.206
184832222008PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.106
229522292012Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.102
146277022004Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.87
163620502005Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.56
209762032010Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.56
267250102016KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.46
159942942005Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer.31
213600542011New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).29
2687824020167SK-BAF axis controls pervasive transcription at enhancers.28

Citation

Dessen P

RN7SK (RNA component of 7SK nuclear ribonucleoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2017-05-01

Online version: http://atlasgeneticsoncology.org/gene/56900/rn7sk