Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RNASEH2A (ribonuclease H2 subunit A)

Identity

Alias_namesribonuclease H2, large subunit
Aicardi-Goutieres syndrome 4
ribonuclease H2, subunit A
Alias_symbol (synonym)RNASEHI
RNHIA
RNHL
AGS4
Other aliasJUNB
THSD8
HGNC (Hugo) RNASEH2A
LocusID (NCBI) 10535
Atlas_Id 53702
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12806614 and ends at 12813648 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAN2B1 (19p13.2) / RNASEH2A (19p13.2)RNASEH2A (19p13.2) / ASNA1 (19p13.2)RNASEH2A (19p13.2) / BEST2 (19p13.2)
RNASEH2A 19p13.2 / BEST2 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  RNASEH2A/BEST2 (19p13)

External links

Nomenclature
HGNC (Hugo)RNASEH2A   18518
LRG (Locus Reference Genomic)LRG_278
Cards
Entrez_Gene (NCBI)RNASEH2A  10535  ribonuclease H2 subunit A
AliasesAGS4; JUNB; RNASEHI; RNHIA; 
RNHL; THSD8
GeneCards (Weizmann)RNASEH2A
Ensembl hg19 (Hinxton)ENSG00000104889 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104889 [Gene_View]  ENSG00000104889 [Sequence]  chr19:12806614-12813648 [Contig_View]  RNASEH2A [Vega]
ICGC DataPortalENSG00000104889
TCGA cBioPortalRNASEH2A
AceView (NCBI)RNASEH2A
Genatlas (Paris)RNASEH2A
WikiGenes10535
SOURCE (Princeton)RNASEH2A
Genetics Home Reference (NIH)RNASEH2A
Genomic and cartography
GoldenPath hg38 (UCSC)RNASEH2A  -     chr19:12806614-12813648 +  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RNASEH2A  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathRNASEH2A - 19p13.13 [CytoView hg19]  RNASEH2A - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000104889
Mapping of homologs : NCBIRNASEH2A [Mapview hg19]  RNASEH2A [Mapview hg38]
OMIM606034   610333   
Gene and transcription
Genbank (Entrez)AK315327 AY363912 BC011748 BE560339 BG825340
RefSeq transcript (Entrez)NM_006397
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RNASEH2A
Cluster EST : UnigeneHs.532851 [ NCBI ]
CGAP (NCI)Hs.532851
Alternative Splicing GalleryENSG00000104889
Gene ExpressionRNASEH2A [ NCBI-GEO ]   RNASEH2A [ EBI - ARRAY_EXPRESS ]   RNASEH2A [ SEEK ]   RNASEH2A [ MEM ]
Gene Expression Viewer (FireBrowse)RNASEH2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10535
GTEX Portal (Tissue expression)RNASEH2A
Human Protein AtlasENSG00000104889-RNASEH2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75792   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75792  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75792
Splice isoforms : SwissVarO75792
Catalytic activity : Enzyme3.1.26.- [ Enzyme-Expasy ]   3.1.26.-3.1.26.- [ IntEnz-EBI ]   3.1.26.- [ BRENDA ]   3.1.26.- [ KEGG ]   
PhosPhoSitePlusO75792
Domains : Interpro (EBI)RNase_H2_suA    RNase_HII/HIII    RNase_HII/HIII_dom    RNase_HII_hlx-loop-hlx_cap_dom    RNaseH-like_sf    RNaseH_sf   
Domain families : Pfam (Sanger)RNase_HII (PF01351)   
Domain families : Pfam (NCBI)pfam01351   
Conserved Domain (NCBI)RNASEH2A
DMDM Disease mutations10535
Blocks (Seattle)RNASEH2A
PDB (RSDB)3P56    3PUF   
PDB Europe3P56    3PUF   
PDB (PDBSum)3P56    3PUF   
PDB (IMB)3P56    3PUF   
Structural Biology KnowledgeBase3P56    3PUF   
SCOP (Structural Classification of Proteins)3P56    3PUF   
CATH (Classification of proteins structures)3P56    3PUF   
SuperfamilyO75792
Human Protein Atlas [tissue]ENSG00000104889-RNASEH2A [tissue]
Peptide AtlasO75792
HPRD06914
IPIIPI00290192   
Protein Interaction databases
DIP (DOE-UCLA)O75792
IntAct (EBI)O75792
FunCoupENSG00000104889
BioGRIDRNASEH2A
STRING (EMBL)RNASEH2A
ZODIACRNASEH2A
Ontologies - Pathways
QuickGOO75792
Ontology : AmiGORNA binding  RNA-DNA hybrid ribonuclease activity  RNA-DNA hybrid ribonuclease activity  ribonuclease activity  nucleoplasm  cytosol  DNA replication  mismatch repair  mismatch repair  RNA catabolic process  ribonuclease H2 complex  ribonuclease H2 complex  DNA replication, removal of RNA primer  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Ontology : EGO-EBIRNA binding  RNA-DNA hybrid ribonuclease activity  RNA-DNA hybrid ribonuclease activity  ribonuclease activity  nucleoplasm  cytosol  DNA replication  mismatch repair  mismatch repair  RNA catabolic process  ribonuclease H2 complex  ribonuclease H2 complex  DNA replication, removal of RNA primer  metal ion binding  RNA phosphodiester bond hydrolysis, endonucleolytic  
Pathways : KEGGDNA replication   
NDEx NetworkRNASEH2A
Atlas of Cancer Signalling NetworkRNASEH2A
Wikipedia pathwaysRNASEH2A
Orthology - Evolution
OrthoDB10535
GeneTree (enSembl)ENSG00000104889
Phylogenetic Trees/Animal Genes : TreeFamRNASEH2A
HOGENOMO75792
Homologs : HomoloGeneRNASEH2A
Homology/Alignments : Family Browser (UCSC)RNASEH2A
Gene fusions - Rearrangements
Fusion : MitelmanRNASEH2A/BEST2 [19p13.2/19p13.2]  
Fusion PortalRNASEH2A 19p13.2 BEST2 19p13.2 LUSC
Fusion : QuiverRNASEH2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRNASEH2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RNASEH2A
dbVarRNASEH2A
ClinVarRNASEH2A
1000_GenomesRNASEH2A 
Exome Variant ServerRNASEH2A
ExAC (Exome Aggregation Consortium)ENSG00000104889
GNOMAD BrowserENSG00000104889
Varsome BrowserRNASEH2A
Genetic variants : HAPMAP10535
Genomic Variants (DGV)RNASEH2A [DGVbeta]
DECIPHERRNASEH2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRNASEH2A 
Mutations
ICGC Data PortalRNASEH2A 
TCGA Data PortalRNASEH2A 
Broad Tumor PortalRNASEH2A
OASIS PortalRNASEH2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRNASEH2A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRNASEH2A
Mutations and Diseases : HGMDRNASEH2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch RNASEH2A
DgiDB (Drug Gene Interaction Database)RNASEH2A
DoCM (Curated mutations)RNASEH2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RNASEH2A (select a term)
intoGenRNASEH2A
Cancer3DRNASEH2A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606034    610333   
Orphanet1309   
DisGeNETRNASEH2A
MedgenRNASEH2A
Genetic Testing Registry RNASEH2A
NextProtO75792 [Medical]
TSGene10535
GENETestsRNASEH2A
Target ValidationRNASEH2A
Huge Navigator RNASEH2A [HugePedia]
snp3D : Map Gene to Disease10535
BioCentury BCIQRNASEH2A
ClinGenRNASEH2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10535
Chemical/Pharm GKB GenePA38565
Clinical trialRNASEH2A
Miscellaneous
canSAR (ICR)RNASEH2A (select the gene name)
DataMed IndexRNASEH2A
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRNASEH2A
EVEXRNASEH2A
GoPubMedRNASEH2A
iHOPRNASEH2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:05:07 CET 2019
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