RNF144A (ring finger protein 144A)

2007-04-01  

Identity

HGNC
RNF144A
LOCATION
2p25.1
LOCUSID
9781
ALIAS
RNF144,UBCE7IP4,hUIP4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9781
HGNC: 20457
Ensembl: ENSG00000151692

Variants:

dbSNP: 9781
ClinVar: 9781
TCGA: ENSG00000151692
COSMIC: RNF144A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151692ENST00000320892P50876
ENSG00000151692ENST00000416587C9JLH4
ENSG00000151692ENST00000432850H7C3G0
ENSG00000151692ENST00000433456C9JLH4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166128121cardiotoxicityDiseaseMultilinkAnnotationassociated26340055

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
201952662011Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.49
249797662014RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage.17
104318181999A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4.12
262168822015Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.7
301710752018RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.3
294733202018Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4.2

Citation

Dessen P

RNF144A (ring finger protein 144A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47523/rnf144a