RNF144B (ring finger protein 144B)

2007-04-01  

Identity

HGNC
RNF144B
LOCATION
6p22.3
LOCUSID
255488
ALIAS
IBRDC2,PIR2,bA528A10.3,p53RFP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 255488
MIM: 618869
HGNC: 21578
Ensembl: ENSG00000137393

Variants:

dbSNP: 255488
ClinVar: 255488
TCGA: ENSG00000137393
COSMIC: RNF144B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137393ENST00000259939Q7Z419

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
206159662010Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.34
206159662010Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.34
128539822003p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1.18
231283962013PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63.9
297249952018Pir2/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation.2
315092992019RNF144B inhibits LPS-induced inflammatory responses via binding TBK1.1
203000622010IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation.0
275244172017miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation.0

Citation

Dessen P

RNF144B (ring finger protein 144B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46739/rnf144b