RNF146 (ring finger protein 146)

2007-04-01  

Identity

HGNC
LOCATION
6q22.33
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 81847
MIM: 612137
HGNC: 21336
Ensembl: ENSG00000118518

Variants:

dbSNP: 81847
ClinVar: 81847
TCGA: ENSG00000118518
COSMIC: RNF146

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118518ENST00000309649Q9NTX7
ENSG00000118518ENST00000356799V9GYY4
ENSG00000118518ENST00000368314Q9NTX7
ENSG00000118518ENST00000476956V9GYY4
ENSG00000118518ENST00000477776V9GYK9
ENSG00000118518ENST00000480444V9GYK9
ENSG00000118518ENST00000608991Q9NTX7
ENSG00000118518ENST00000609447V9GYK9
ENSG00000118518ENST00000609944V9GZ53
ENSG00000118518ENST00000610153Q9NTX7
ENSG00000118518ENST00000610162A0A0G2JLL7
ENSG00000118518ENST00000616343Q9NTX7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Degradation of AXINREACTOMER-HSA-4641257
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183266232008Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.152
217999112011Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling.82
222674122012Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination.80
218251512011Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.79
253272522015Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.66
222747112011Ring finger protein 146/Iduna is a poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase.14
244548542014Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.13
284301832017Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke.12
158139382005The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.9
195172712009The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women.5

Citation

Dessen P

RNF146 (ring finger protein 146)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47363/rnf146