RNF181 (ring finger protein 181)

2011-09-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
HSPC238

Other Information

Locus ID:

NCBI: 51255
MIM: 612490
HGNC: 28037
Ensembl: ENSG00000168894

Variants:

dbSNP: 51255
ClinVar: 51255
TCGA: ENSG00000168894
COSMIC: RNF181

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168894ENST00000306368Q9P0P0
ENSG00000168894ENST00000414390C9J391
ENSG00000168894ENST00000441634C9J1C6
ENSG00000168894ENST00000443647F8WBU5
ENSG00000168894ENST00000456023H7C426

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
340526762021RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.1
340526762021RN181 regulates the biological behaviors of oral squamous cell carcinoma cells via mediating ERK/MAPK signaling pathway.1
329733332020The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression.15
329733332020The ubiquitin ligase RNF181 stabilizes ERα and modulates breast cancer progression.15
307141502019RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway.10
307141502019RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK-cyclin D1/CDK4 pathway.10
263988552015Screening and verification of proteins that interact with HSPC238.0
267112592015Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.16
263988552015Screening and verification of proteins that interact with HSPC238.0
267112592015Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.16
213912252011RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway.23
213912252011RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway.23
194265952009[Construction of recombinant eukaryotic expression vector pDsRed1-C3/LOC51255 and subcellular localization of LOC51255 protein in HePG2 cell line].0
194265952009[Construction of recombinant eukaryotic expression vector pDsRed1-C3/LOC51255 and subcellular localization of LOC51255 protein in HePG2 cell line].0
183318362008RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3.11

Citation

Dessen P

RNF181 (ring finger protein 181)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52384/rnf181