RNF31 (ring finger protein 31)

2007-02-01 Affiliation

Identity

HGNC

RNF31

LOCATION

14q12

LOCUSID

55072

ALIAS

HOIP,Paul,ZIBRA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55072
MIM: 612487
HGNC: 16031
Ensembl: ENSG00000092098

Variants:

dbSNP: 55072
ClinVar: 55072
TCGA: ENSG00000092098
COSMIC: RNF31

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000092098	ENST00000324103	Q96EP0
ENSG00000092098	ENST00000483895	H0YMN0
ENSG00000092098	ENST00000491351	H0YMG4
ENSG00000092098	ENST00000557991	H0YM13
ENSG00000092098	ENST00000558907	H0YMG8
ENSG00000092098	ENST00000559260	H0YMK6
ENSG00000092098	ENST00000559275	Q96EP0
ENSG00000092098	ENST00000559308	H0YM57
ENSG00000092098	ENST00000559449	H0YNT1
ENSG00000092098	ENST00000559533	H0YNK5
ENSG00000092098	ENST00000559583	A0A494C1G4
ENSG00000092098	ENST00000559719	H0YKI4
ENSG00000092098	ENST00000560071	H0YNC1
ENSG00000092098	ENST00000560787	H0YKX0
ENSG00000092098	ENST00000560875	H0YNJ0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Signal Transduction	REACTOME	R-HSA-162582
Death Receptor Signalling	REACTOME	R-HSA-73887
TNF signaling	REACTOME	R-HSA-75893
TNFR1-induced NFkappaB signaling pathway	REACTOME	R-HSA-5357956
Regulation of TNFR1 signaling	REACTOME	R-HSA-5357905

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23986494	2013	Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.	145
22863777	2012	The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.	87
24141947	2013	Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP.	59
26008899	2015	Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.	59
24726327	2014	Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling.	58
24726323	2014	Molecular basis and regulation of OTULIN-LUBAC interaction.	55
24491438	2014	Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.	51
26038114	2015	Systems-wide analysis of BCR signalosomes and downstream phosphorylation and ubiquitylation.	42
26789245	2016	Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation.	42
27545878	2016	SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.	35

Citation

Dessen P

RNF31 (ring finger protein 31)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46497/rnf31