RNPS1 (RNA binding protein with serine rich domain 1)

2014-11-01 Affiliation

Identity

HGNC

RNPS1

LOCATION

16p13.3

LOCUSID

10921

ALIAS

E5.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10921
MIM: 606447
HGNC: 10080
Ensembl: ENSG00000205937

Variants:

dbSNP: 10921
ClinVar: 10921
TCGA: ENSG00000205937
COSMIC: RNPS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000205937	ENST00000301730	Q15287
ENSG00000205937	ENST00000301730	D3DU92
ENSG00000205937	ENST00000320225	Q15287
ENSG00000205937	ENST00000320225	D3DU92
ENSG00000205937	ENST00000397086	Q15287
ENSG00000205937	ENST00000397086	D3DU92
ENSG00000205937	ENST00000561518	H3BMM9
ENSG00000205937	ENST00000561718	H3BPG5
ENSG00000205937	ENST00000562690	H3BTR6
ENSG00000205937	ENST00000564311	H3BNU7
ENSG00000205937	ENST00000564601	H3BUL0
ENSG00000205937	ENST00000564764	H3BTY0
ENSG00000205937	ENST00000564822	H3BRK4
ENSG00000205937	ENST00000565333	H3BNI3
ENSG00000205937	ENST00000565589	H3BTV0
ENSG00000205937	ENST00000565678	Q15287
ENSG00000205937	ENST00000565678	D3DU92
ENSG00000205937	ENST00000565870	H3BTC0
ENSG00000205937	ENST00000566180	H3BUG0
ENSG00000205937	ENST00000566397	H3BPG5
ENSG00000205937	ENST00000566458	Q15287
ENSG00000205937	ENST00000567147	H3BMS0
ENSG00000205937	ENST00000568631	Q15287
ENSG00000205937	ENST00000568631	D3DU92
ENSG00000205937	ENST00000569598	H3BV80
ENSG00000205937	ENST00000569709	H3BP82

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
RNA transport	KEGG	ko03013
RNA transport	KEGG	hsa03013
mRNA surveillance pathway	KEGG	ko03015
mRNA surveillance pathway	KEGG	hsa03015
Exon junction complex (EJC)	KEGG	hsa_M00430
Exon junction complex (EJC)	KEGG	M00430
Gene Expression	REACTOME	R-HSA-74160
RNA Polymerase II Transcription	REACTOME	R-HSA-73857
RNA Polymerase II Transcription Termination	REACTOME	R-HSA-73856
Cleavage of Growing Transcript in the Termination Region	REACTOME	R-HSA-109688
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
mRNA 3'-end processing	REACTOME	R-HSA-72187
Transport of Mature Transcript to Cytoplasm	REACTOME	R-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing Transcript	REACTOME	R-HSA-159236
Nonsense-Mediated Decay (NMD)	REACTOME	R-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	REACTOME	R-HSA-975957

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11546874	2001	Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.	155
11546873	2001	Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex.	115
17959926	2007	The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability.	21
21508110	2011	Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma.	19
15684395	2005	Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.	14
27990632	2017	RNPS1 is modulated by ubiquitin-specific protease 4.	3

Citation

Dessen P

RNPS1 (RNA binding protein with serine rich domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72723/rnps1