RO60 (Ro60, Y RNA binding protein)

2014-11-01  

Identity

HGNC
LOCATION
1q31.2
LOCUSID
ALIAS
RORNP,SSA2,TROVE2

Other Information

Locus ID:

NCBI: 6738
MIM: 600063
HGNC: 11313
Ensembl: ENSG00000116747

Variants:

dbSNP: 6738
ClinVar: 6738
TCGA: ENSG00000116747
COSMIC: RO60

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116747ENST00000367441P10155
ENSG00000116747ENST00000367441A0A024R983
ENSG00000116747ENST00000367443P10155
ENSG00000116747ENST00000367444P10155
ENSG00000116747ENST00000367445P10155
ENSG00000116747ENST00000367446P10155
ENSG00000116747ENST00000367446A0A024R983
ENSG00000116747ENST00000400968P10155
ENSG00000116747ENST00000400968A0A024R983
ENSG00000116747ENST00000415442D6RE09
ENSG00000116747ENST00000432079G5E9R9
ENSG00000116747ENST00000506303D6RDN1
ENSG00000116747ENST00000512587H0Y9N5

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322

References

Pubmed IDYearTitleCitations
263828532015The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression.53
180564222007Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.38
200897052010Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block.35
159283452005RNA chaperone activity of protein components of human Ro RNPs.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
20224770201060 kD Ro and nRNP A frequently initiate human lupus autoimmunity.20
221143172012The zipcode-binding protein ZBP1 influences the subcellular location of the Ro 60-kDa autoantigen and the noncoding Y3 RNA.19
210606852010Ribonucleoprotein particles containing non-coding Y RNAs, Ro60, La and nucleolin are not required for Y RNA function in DNA replication.17
236987472013Ro60 requires Y3 RNA for cell surface exposure and inflammation associated with cardiac manifestations of neonatal lupus.16
159648422005Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.10

Citation

Dessen P

RO60 (Ro60, Y RNA binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75207/ro60