RORC (RAR related orphan receptor C)

2007-04-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
IMD42,NR1F3,RORG,RZR-GAMMA,RZRG,TOR
FUSION GENES

Other Information

Locus ID:

NCBI: 6097
MIM: 602943
HGNC: 10260
Ensembl: ENSG00000143365

Variants:

dbSNP: 6097
ClinVar: 6097
TCGA: ENSG00000143365
COSMIC: RORC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143365ENST00000318247P51449
ENSG00000143365ENST00000318247Q6I9R9
ENSG00000143365ENST00000356728P51449
ENSG00000143365ENST00000356728F1D8P6
ENSG00000143365ENST00000638901A0A1W2PRM4
ENSG00000143365ENST00000651814A0A494C0S6
ENSG00000143365ENST00000651893A0A494C174
ENSG00000143365ENST00000652040A0A494C0H2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

References

Pubmed IDYearTitleCitations
190299042009Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin.199
184343252008Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat.136
261603762015IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations.108
194396512009Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.106
246687542014RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.81
119831532002Nuclear hormone receptors in T lymphocytes.78
199658672010Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands.68
202031002010Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORgamma.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215661342011Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein.60

Citation

Dessen P

RORC (RAR related orphan receptor C)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47292/rorc