RORC (RAR related orphan receptor C)

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RORC (RAR related orphan receptor C)

Identity

Alias (NCBI)	IMD42
	NR1F3
	RORG
	RZR-GAMMA
	RZRG
	TOR
HGNC (Hugo)	RORC
HGNC Alias symb	RZRG
	RORG
	NR1F3
	TOR
HGNC Previous name	RAR-related orphan receptor C
LocusID (NCBI)	6097
Atlas_Id	47292
Location	1q21.3 [Link to chromosome band 1q21]
Location_base_pair	Starts at 151806071 and ends at 151831802 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

VPS72 (1q21.3) / RORC (1q21.3)

VPS72 1q21.3 / RORC 1q21.3

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

VPS72/RORC (1q21)

External links

	Nomenclature
HGNC (Hugo)	RORC 10260
	Cards
Entrez_Gene (NCBI)	RORC 6097 RAR related orphan receptor C
Aliases	IMD42; NR1F3; RORG; RZR-GAMMA;
	RZRG; TOR
GeneCards (Weizmann)	RORC
Ensembl hg19 (Hinxton)	ENSG00000143365 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000143365 [Gene_View] ENSG00000143365 [Sequence] chr1:151806071-151831802 [Contig_View] RORC [Vega]
ICGC DataPortal	ENSG00000143365
TCGA cBioPortal	RORC
AceView (NCBI)	RORC
Genatlas (Paris)	RORC
WikiGenes	6097
SOURCE (Princeton)	RORC
Genetics Home Reference (NIH)	RORC
	Genomic and cartography
GoldenPath hg38 (UCSC)	RORC - chr1:151806071-151831802 - 1q21.3 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	RORC - 1q21.3 [Description] (hg19-Feb_2009)
GoldenPath	RORC - 1q21.3 [CytoView hg19] RORC - 1q21.3 [CytoView hg38]
ImmunoBase	ENSG00000143365
genome Data Viewer NCBI	RORC [Mapview hg19]
OMIM	602943 616622
	Gene and transcription
Genbank (Entrez)	AB307696 AF075096 AK097994 AK128522 AK223137
RefSeq transcript (Entrez)	NM_001001523 NM_005060
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	RORC
Alternative Splicing Gallery	ENSG00000143365
Gene Expression	RORC [ NCBI-GEO ] RORC [ EBI - ARRAY_EXPRESS ] RORC [ SEEK ] RORC [ MEM ]
Gene Expression Viewer (FireBrowse)	RORC [ Firebrowse - Broad ]
Genevisible	Expression of RORC in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	6097
GTEX Portal (Tissue expression)	RORC
Human Protein Atlas	ENSG00000143365-RORC [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P51449 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P51449 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P51449
Splice isoforms : SwissVar	P51449
PhosPhoSitePlus	P51449
Domaine pattern : Prosite (Expaxy)	NR_LBD (PS51843) NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030)
Domains : Interpro (EBI)	NHR-like_dom_sf Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt ROR_rcpt Znf_hrmn_rcpt Znf_NHR/GATA
Domain families : Pfam (Sanger)	Hormone_recep (PF00104) zf-C4 (PF00105)
Domain families : Pfam (NCBI)	pfam00104 pfam00105
Domain families : Smart (EMBL)	HOLI (SM00430) ZnF_C4 (SM00399)
Conserved Domain (NCBI)	RORC
DMDM Disease mutations	6097
Blocks (Seattle)	RORC
PDB (RSDB)	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6NAD 6NWS 6NWT 6NWU 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6U25
PDB Europe	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6NAD 6NWS 6NWT 6NWU 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6U25
PDB (PDBSum)	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6NAD 6NWS 6NWT 6NWU 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6U25
PDB (IMB)	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6NAD 6NWS 6NWT 6NWU 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6U25
Structural Biology KnowledgeBase	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6NAD 6NWS 6NWT 6NWU 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6U25
SCOP (Structural Classification of Proteins)	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6NAD 6NWS 6NWT 6NWU 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6U25
CATH (Classification of proteins structures)	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6NAD 6NWS 6NWT 6NWU 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6U25
Superfamily	P51449
Human Protein Atlas [tissue]	ENSG00000143365-RORC [tissue]
Peptide Atlas	P51449
HPRD	04250
IPI	IPI00216710 IPI00418178 IPI00909441 IPI00955841
	Protein Interaction databases
DIP (DOE-UCLA)	P51449
IntAct (EBI)	P51449
FunCoup	ENSG00000143365
BioGRID	RORC
STRING (EMBL)	RORC
ZODIAC	RORC
	Ontologies - Pathways
QuickGO	P51449
Ontology : AmiGO	negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm transcription initiation from RNA polymerase II promoter xenobiotic metabolic process oxysterol binding oxysterol binding zinc ion binding regulation of glucose metabolic process nuclear body regulation of steroid metabolic process cytokine-mediated signaling pathway intracellular receptor signaling pathway circadian regulation of gene expression cellular response to sterol host cell nucleus positive regulation of circadian rhythm steroid hormone mediated signaling pathway regulation of fat cell differentiation positive regulation of transcription, DNA-templated adipose tissue development regulation of transcription involved in cell fate commitment T-helper 17 cell differentiation transcription factor activity, direct ligand regulated sequence-specific DNA binding
Ontology : EGO-EBI	negative regulation of transcription by RNA polymerase II nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm transcription initiation from RNA polymerase II promoter xenobiotic metabolic process oxysterol binding oxysterol binding zinc ion binding regulation of glucose metabolic process nuclear body regulation of steroid metabolic process cytokine-mediated signaling pathway intracellular receptor signaling pathway circadian regulation of gene expression cellular response to sterol host cell nucleus positive regulation of circadian rhythm steroid hormone mediated signaling pathway regulation of fat cell differentiation positive regulation of transcription, DNA-templated adipose tissue development regulation of transcription involved in cell fate commitment T-helper 17 cell differentiation transcription factor activity, direct ligand regulated sequence-specific DNA binding
Pathways : KEGG	Circadian rhythm Inflammatory bowel disease (IBD)
NDEx Network	RORC
Atlas of Cancer Signalling Network	RORC
Wikipedia pathways	RORC
	Orthology - Evolution
OrthoDB	6097
GeneTree (enSembl)	ENSG00000143365
Phylogenetic Trees/Animal Genes : TreeFam	RORC
HOGENOM	P51449
Homologs : HomoloGene	RORC
Homology/Alignments : Family Browser (UCSC)	RORC
	Gene fusions - Rearrangements
Fusion : Mitelman	VPS72/RORC [1q21.3/1q21.3]
Fusion Portal	VPS72 1q21.3 RORC 1q21.3 LUAD
Fusion : Quiver	RORC
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	RORC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	RORC
dbVar	RORC
ClinVar	RORC
1000_Genomes	RORC
Exome Variant Server	RORC
GNOMAD Browser	ENSG00000143365
Varsome Browser	RORC
Genetic variants : HAPMAP	6097
Genomic Variants (DGV)	RORC [DGVbeta]
DECIPHER	RORC [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	RORC
	Mutations
ICGC Data Portal	RORC
TCGA Data Portal	RORC
Broad Tumor Portal	RORC
OASIS Portal	RORC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	RORC [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	RORC
Mutations and Diseases : HGMD	RORC
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search RORC
DgiDB (Drug Gene Interaction Database)	RORC
DoCM (Curated mutations)	RORC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	RORC (select a term)
intoGen	RORC
Cancer3D	RORC(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	602943 616622
Orphanet
DisGeNET	RORC
Medgen	RORC
Genetic Testing Registry	RORC
NextProt	P51449 [Medical]
TSGene	6097
GENETests	RORC
Target Validation	RORC
Huge Navigator	RORC [HugePedia]
snp3D : Map Gene to Disease	6097
BioCentury BCIQ	RORC
ClinGen	RORC
	Clinical trials, drugs, therapy
Protein Interactions : CTD	6097
Pharm GKB Gene	PA34632
Clinical trial	RORC
	Miscellaneous
canSAR (ICR)	RORC (select the gene name)
Harmonizome	RORC
DataMed Index	RORC
	Probes
	Litterature
PubMed	130 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	RORC
EVEX	RORC
GoPubMed	RORC

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Thu Jul 16 15:33:53 CEST 2020

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

RORC (RAR related orphan receptor C)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute