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RORC (RAR related orphan receptor C)

Identity

Alias (NCBI)IMD42
NR1F3
RORG
RZR-GAMMA
RZRG
TOR
HGNC (Hugo) RORC
HGNC Alias symbRZRG
RORG
NR1F3
TOR
HGNC Previous nameRAR-related orphan receptor C
LocusID (NCBI) 6097
Atlas_Id 47292
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 151806071 and ends at 151831802 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
VPS72 (1q21.3) / RORC (1q21.3)VPS72 1q21.3 / RORC 1q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  VPS72/RORC (1q21)


External links

Nomenclature
HGNC (Hugo)RORC   10260
Cards
Entrez_Gene (NCBI)RORC  6097  RAR related orphan receptor C
AliasesIMD42; NR1F3; RORG; RZR-GAMMA; 
RZRG; TOR
GeneCards (Weizmann)RORC
Ensembl hg19 (Hinxton)ENSG00000143365 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143365 [Gene_View]  ENSG00000143365 [Sequence]  chr1:151806071-151831802 [Contig_View]  RORC [Vega]
ICGC DataPortalENSG00000143365
TCGA cBioPortalRORC
AceView (NCBI)RORC
Genatlas (Paris)RORC
WikiGenes6097
SOURCE (Princeton)RORC
Genetics Home Reference (NIH)RORC
Genomic and cartography
GoldenPath hg38 (UCSC)RORC  -     chr1:151806071-151831802 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RORC  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathRORC - 1q21.3 [CytoView hg19]  RORC - 1q21.3 [CytoView hg38]
ImmunoBaseENSG00000143365
genome Data Viewer NCBIRORC [Mapview hg19]  
OMIM602943   616622   
Gene and transcription
Genbank (Entrez)AB307696 AF075096 AK097994 AK128522 AK223137
RefSeq transcript (Entrez)NM_001001523 NM_005060
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RORC
Alternative Splicing GalleryENSG00000143365
Gene ExpressionRORC [ NCBI-GEO ]   RORC [ EBI - ARRAY_EXPRESS ]   RORC [ SEEK ]   RORC [ MEM ]
Gene Expression Viewer (FireBrowse)RORC [ Firebrowse - Broad ]
GenevisibleExpression of RORC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6097
GTEX Portal (Tissue expression)RORC
Human Protein AtlasENSG00000143365-RORC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51449   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51449  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51449
Splice isoforms : SwissVarP51449
PhosPhoSitePlusP51449
Domaine pattern : Prosite (Expaxy)NR_LBD (PS51843)    NUCLEAR_REC_DBD_1 (PS00031)    NUCLEAR_REC_DBD_2 (PS51030)   
Domains : Interpro (EBI)NHR-like_dom_sf    Nucl_hrmn_rcpt_lig-bd    Nuclear_hrmn_rcpt    ROR_rcpt    Znf_hrmn_rcpt    Znf_NHR/GATA   
Domain families : Pfam (Sanger)Hormone_recep (PF00104)    zf-C4 (PF00105)   
Domain families : Pfam (NCBI)pfam00104    pfam00105   
Domain families : Smart (EMBL)HOLI (SM00430)  ZnF_C4 (SM00399)  
Conserved Domain (NCBI)RORC
DMDM Disease mutations6097
Blocks (Seattle)RORC
PDB (RSDB)3B0W    3KYT    3L0J    3L0L    4NB6    4NIE    4QM0    4S14    4WLB    4WPF    4WQP    4XT9    4YMQ    4YPQ    4ZJR    4ZJW    4ZOM    5APH    5APJ    5APK    5AYG    5C4O    5C4S    5C4T    5C4U    5EJV    5ETH    5G42    5G43    5G44    5G45    5G46    5IXK    5IZ0    5K38    5K3L    5K3M    5K3N    5K6E    5K74    5LWP    5M96    5NI5    5NI7    5NI8    5NIB    5NTI    5NTK    5NTN    5NTP    5NTQ    5NTW    5NU1    5UFO    5UFR    5UHI    5VB3    5VB5    5VB6    5VB7    5VQK    5VQL    5W4R    5W4V    5X8Q    5YP5    5YP6    5ZA1    6A22    6B30    6B31    6B33    6BN6    6BR2    6BR3    6CN5    6CN6    6CVH    6E3E    6E3G    6ESN    6FGQ    6FZU    6G05    6G07    6IVX    6J1L    6J3N    6NAD    6NWS    6NWT    6NWU    6O98    6P9F    6Q2W    6Q6M    6Q6O    6Q7A    6Q7H    6R7A    6R7J    6R7K    6SAL    6U25   
PDB Europe3B0W    3KYT    3L0J    3L0L    4NB6    4NIE    4QM0    4S14    4WLB    4WPF    4WQP    4XT9    4YMQ    4YPQ    4ZJR    4ZJW    4ZOM    5APH    5APJ    5APK    5AYG    5C4O    5C4S    5C4T    5C4U    5EJV    5ETH    5G42    5G43    5G44    5G45    5G46    5IXK    5IZ0    5K38    5K3L    5K3M    5K3N    5K6E    5K74    5LWP    5M96    5NI5    5NI7    5NI8    5NIB    5NTI    5NTK    5NTN    5NTP    5NTQ    5NTW    5NU1    5UFO    5UFR    5UHI    5VB3    5VB5    5VB6    5VB7    5VQK    5VQL    5W4R    5W4V    5X8Q    5YP5    5YP6    5ZA1    6A22    6B30    6B31    6B33    6BN6    6BR2    6BR3    6CN5    6CN6    6CVH    6E3E    6E3G    6ESN    6FGQ    6FZU    6G05    6G07    6IVX    6J1L    6J3N    6NAD    6NWS    6NWT    6NWU    6O98    6P9F    6Q2W    6Q6M    6Q6O    6Q7A    6Q7H    6R7A    6R7J    6R7K    6SAL    6U25   
PDB (PDBSum)3B0W    3KYT    3L0J    3L0L    4NB6    4NIE    4QM0    4S14    4WLB    4WPF    4WQP    4XT9    4YMQ    4YPQ    4ZJR    4ZJW    4ZOM    5APH    5APJ    5APK    5AYG    5C4O    5C4S    5C4T    5C4U    5EJV    5ETH    5G42    5G43    5G44    5G45    5G46    5IXK    5IZ0    5K38    5K3L    5K3M    5K3N    5K6E    5K74    5LWP    5M96    5NI5    5NI7    5NI8    5NIB    5NTI    5NTK    5NTN    5NTP    5NTQ    5NTW    5NU1    5UFO    5UFR    5UHI    5VB3    5VB5    5VB6    5VB7    5VQK    5VQL    5W4R    5W4V    5X8Q    5YP5    5YP6    5ZA1    6A22    6B30    6B31    6B33    6BN6    6BR2    6BR3    6CN5    6CN6    6CVH    6E3E    6E3G    6ESN    6FGQ    6FZU    6G05    6G07    6IVX    6J1L    6J3N    6NAD    6NWS    6NWT    6NWU    6O98    6P9F    6Q2W    6Q6M    6Q6O    6Q7A    6Q7H    6R7A    6R7J    6R7K    6SAL    6U25   
PDB (IMB)3B0W    3KYT    3L0J    3L0L    4NB6    4NIE    4QM0    4S14    4WLB    4WPF    4WQP    4XT9    4YMQ    4YPQ    4ZJR    4ZJW    4ZOM    5APH    5APJ    5APK    5AYG    5C4O    5C4S    5C4T    5C4U    5EJV    5ETH    5G42    5G43    5G44    5G45    5G46    5IXK    5IZ0    5K38    5K3L    5K3M    5K3N    5K6E    5K74    5LWP    5M96    5NI5    5NI7    5NI8    5NIB    5NTI    5NTK    5NTN    5NTP    5NTQ    5NTW    5NU1    5UFO    5UFR    5UHI    5VB3    5VB5    5VB6    5VB7    5VQK    5VQL    5W4R    5W4V    5X8Q    5YP5    5YP6    5ZA1    6A22    6B30    6B31    6B33    6BN6    6BR2    6BR3    6CN5    6CN6    6CVH    6E3E    6E3G    6ESN    6FGQ    6FZU    6G05    6G07    6IVX    6J1L    6J3N    6NAD    6NWS    6NWT    6NWU    6O98    6P9F    6Q2W    6Q6M    6Q6O    6Q7A    6Q7H    6R7A    6R7J    6R7K    6SAL    6U25   
Structural Biology KnowledgeBase3B0W    3KYT    3L0J    3L0L    4NB6    4NIE    4QM0    4S14    4WLB    4WPF    4WQP    4XT9    4YMQ    4YPQ    4ZJR    4ZJW    4ZOM    5APH    5APJ    5APK    5AYG    5C4O    5C4S    5C4T    5C4U    5EJV    5ETH    5G42    5G43    5G44    5G45    5G46    5IXK    5IZ0    5K38    5K3L    5K3M    5K3N    5K6E    5K74    5LWP    5M96    5NI5    5NI7    5NI8    5NIB    5NTI    5NTK    5NTN    5NTP    5NTQ    5NTW    5NU1    5UFO    5UFR    5UHI    5VB3    5VB5    5VB6    5VB7    5VQK    5VQL    5W4R    5W4V    5X8Q    5YP5    5YP6    5ZA1    6A22    6B30    6B31    6B33    6BN6    6BR2    6BR3    6CN5    6CN6    6CVH    6E3E    6E3G    6ESN    6FGQ    6FZU    6G05    6G07    6IVX    6J1L    6J3N    6NAD    6NWS    6NWT    6NWU    6O98    6P9F    6Q2W    6Q6M    6Q6O    6Q7A    6Q7H    6R7A    6R7J    6R7K    6SAL    6U25   
SCOP (Structural Classification of Proteins)3B0W    3KYT    3L0J    3L0L    4NB6    4NIE    4QM0    4S14    4WLB    4WPF    4WQP    4XT9    4YMQ    4YPQ    4ZJR    4ZJW    4ZOM    5APH    5APJ    5APK    5AYG    5C4O    5C4S    5C4T    5C4U    5EJV    5ETH    5G42    5G43    5G44    5G45    5G46    5IXK    5IZ0    5K38    5K3L    5K3M    5K3N    5K6E    5K74    5LWP    5M96    5NI5    5NI7    5NI8    5NIB    5NTI    5NTK    5NTN    5NTP    5NTQ    5NTW    5NU1    5UFO    5UFR    5UHI    5VB3    5VB5    5VB6    5VB7    5VQK    5VQL    5W4R    5W4V    5X8Q    5YP5    5YP6    5ZA1    6A22    6B30    6B31    6B33    6BN6    6BR2    6BR3    6CN5    6CN6    6CVH    6E3E    6E3G    6ESN    6FGQ    6FZU    6G05    6G07    6IVX    6J1L    6J3N    6NAD    6NWS    6NWT    6NWU    6O98    6P9F    6Q2W    6Q6M    6Q6O    6Q7A    6Q7H    6R7A    6R7J    6R7K    6SAL    6U25   
CATH (Classification of proteins structures)3B0W    3KYT    3L0J    3L0L    4NB6    4NIE    4QM0    4S14    4WLB    4WPF    4WQP    4XT9    4YMQ    4YPQ    4ZJR    4ZJW    4ZOM    5APH    5APJ    5APK    5AYG    5C4O    5C4S    5C4T    5C4U    5EJV    5ETH    5G42    5G43    5G44    5G45    5G46    5IXK    5IZ0    5K38    5K3L    5K3M    5K3N    5K6E    5K74    5LWP    5M96    5NI5    5NI7    5NI8    5NIB    5NTI    5NTK    5NTN    5NTP    5NTQ    5NTW    5NU1    5UFO    5UFR    5UHI    5VB3    5VB5    5VB6    5VB7    5VQK    5VQL    5W4R    5W4V    5X8Q    5YP5    5YP6    5ZA1    6A22    6B30    6B31    6B33    6BN6    6BR2    6BR3    6CN5    6CN6    6CVH    6E3E    6E3G    6ESN    6FGQ    6FZU    6G05    6G07    6IVX    6J1L    6J3N    6NAD    6NWS    6NWT    6NWU    6O98    6P9F    6Q2W    6Q6M    6Q6O    6Q7A    6Q7H    6R7A    6R7J    6R7K    6SAL    6U25   
SuperfamilyP51449
Human Protein Atlas [tissue]ENSG00000143365-RORC [tissue]
Peptide AtlasP51449
HPRD04250
IPIIPI00216710   IPI00418178   IPI00909441   IPI00955841   
Protein Interaction databases
DIP (DOE-UCLA)P51449
IntAct (EBI)P51449
FunCoupENSG00000143365
BioGRIDRORC
STRING (EMBL)RORC
ZODIACRORC
Ontologies - Pathways
QuickGOP51449
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  xenobiotic metabolic process  oxysterol binding  oxysterol binding  zinc ion binding  regulation of glucose metabolic process  nuclear body  regulation of steroid metabolic process  cytokine-mediated signaling pathway  intracellular receptor signaling pathway  circadian regulation of gene expression  cellular response to sterol  host cell nucleus  positive regulation of circadian rhythm  steroid hormone mediated signaling pathway  regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  adipose tissue development  regulation of transcription involved in cell fate commitment  T-helper 17 cell differentiation  transcription factor activity, direct ligand regulated sequence-specific DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  transcription coactivator binding  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription factor activity  steroid hormone receptor activity  nuclear receptor activity  protein binding  nucleus  nucleus  nucleoplasm  transcription initiation from RNA polymerase II promoter  xenobiotic metabolic process  oxysterol binding  oxysterol binding  zinc ion binding  regulation of glucose metabolic process  nuclear body  regulation of steroid metabolic process  cytokine-mediated signaling pathway  intracellular receptor signaling pathway  circadian regulation of gene expression  cellular response to sterol  host cell nucleus  positive regulation of circadian rhythm  steroid hormone mediated signaling pathway  regulation of fat cell differentiation  positive regulation of transcription, DNA-templated  adipose tissue development  regulation of transcription involved in cell fate commitment  T-helper 17 cell differentiation  transcription factor activity, direct ligand regulated sequence-specific DNA binding  
Pathways : KEGGCircadian rhythm    Inflammatory bowel disease (IBD)   
NDEx NetworkRORC
Atlas of Cancer Signalling NetworkRORC
Wikipedia pathwaysRORC
Orthology - Evolution
OrthoDB6097
GeneTree (enSembl)ENSG00000143365
Phylogenetic Trees/Animal Genes : TreeFamRORC
HOGENOMP51449
Homologs : HomoloGeneRORC
Homology/Alignments : Family Browser (UCSC)RORC
Gene fusions - Rearrangements
Fusion : MitelmanVPS72/RORC [1q21.3/1q21.3]  
Fusion PortalVPS72 1q21.3 RORC 1q21.3 LUAD
Fusion : QuiverRORC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRORC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RORC
dbVarRORC
ClinVarRORC
1000_GenomesRORC 
Exome Variant ServerRORC
GNOMAD BrowserENSG00000143365
Varsome BrowserRORC
Genetic variants : HAPMAP6097
Genomic Variants (DGV)RORC [DGVbeta]
DECIPHERRORC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRORC 
Mutations
ICGC Data PortalRORC 
TCGA Data PortalRORC 
Broad Tumor PortalRORC
OASIS PortalRORC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRORC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DRORC
Mutations and Diseases : HGMDRORC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RORC
DgiDB (Drug Gene Interaction Database)RORC
DoCM (Curated mutations)RORC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RORC (select a term)
intoGenRORC
Cancer3DRORC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602943    616622   
Orphanet
DisGeNETRORC
MedgenRORC
Genetic Testing Registry RORC
NextProtP51449 [Medical]
TSGene6097
GENETestsRORC
Target ValidationRORC
Huge Navigator RORC [HugePedia]
snp3D : Map Gene to Disease6097
BioCentury BCIQRORC
ClinGenRORC
Clinical trials, drugs, therapy
Protein Interactions : CTD6097
Pharm GKB GenePA34632
Clinical trialRORC
Miscellaneous
canSAR (ICR)RORC (select the gene name)
HarmonizomeRORC
DataMed IndexRORC
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRORC
EVEXRORC
GoPubMedRORC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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