| Nomenclature |
|---|
| HGNC (Hugo) | RORC 10260 |
| Cards |
|---|
| Entrez_Gene (NCBI) | RORC 6097 RAR related orphan receptor C |
| Aliases | IMD42; NR1F3; RORG; RZR-GAMMA; |
| RZRG; TOR |
| GeneCards (Weizmann) | RORC |
| Ensembl hg19 (Hinxton) | ENSG00000143365 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000143365 [Gene_View] ENSG00000143365 [Sequence] chr1:151806071-151831872 [Contig_View] RORC [Vega] |
| ICGC DataPortal | ENSG00000143365 |
| TCGA cBioPortal | RORC |
| AceView (NCBI) | RORC |
| Genatlas (Paris) | RORC |
| WikiGenes | 6097 |
| SOURCE (Princeton) | RORC |
| Genetics Home Reference (NIH) | RORC |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | RORC - chr1:151806071-151831872 - 1q21.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | RORC - 1q21.3 [Description] (hg19-Feb_2009) |
| GoldenPath | RORC - 1q21.3 [CytoView hg19] RORC - 1q21.3 [CytoView hg38] |
| ImmunoBase | ENSG00000143365 |
| Mapping of homologs : NCBI | RORC [Mapview hg19] RORC [Mapview hg38] |
| OMIM | 602943 616622 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB307696 AF075096 AK097994 AK128522 AK223137 |
| RefSeq transcript (Entrez) | NM_001001523 NM_005060 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | RORC |
| Cluster EST : Unigene | Hs.607993 [ NCBI ] |
| CGAP (NCI) | Hs.607993 |
| Alternative Splicing Gallery | ENSG00000143365 |
| Gene Expression | RORC [ NCBI-GEO ] RORC [ EBI - ARRAY_EXPRESS ]
RORC [ SEEK ] RORC [ MEM ] |
| Gene Expression Viewer (FireBrowse) | RORC [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 6097 |
| GTEX Portal (Tissue expression) | RORC |
| Human Protein Atlas | ENSG00000143365-RORC [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P51449 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P51449 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P51449 |
| Splice isoforms : SwissVar | P51449 |
| PhosPhoSitePlus | P51449 |
| Domaine pattern : Prosite (Expaxy) | NR_LBD (PS51843) NUCLEAR_REC_DBD_1 (PS00031) NUCLEAR_REC_DBD_2 (PS51030) |
| Domains : Interpro (EBI) | NHR_like_dom_sf Nucl_hrmn_rcpt_lig-bd Nuclear_hrmn_rcpt ROR_rcpt Znf_hrmn_rcpt Znf_NHR/GATA |
| Domain families : Pfam (Sanger) | Hormone_recep (PF00104) zf-C4 (PF00105) |
| Domain families : Pfam (NCBI) | pfam00104 pfam00105 |
| Domain families : Smart (EMBL) | HOLI (SM00430) ZnF_C4 (SM00399) |
| Conserved Domain (NCBI) | RORC |
| DMDM Disease mutations | 6097 |
| Blocks (Seattle) | RORC |
| PDB (RSDB) | 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5W4R 5W4V 5X8Q 5YP6 6B30 6BN6 |
| PDB Europe | 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5W4R 5W4V 5X8Q 5YP6 6B30 6BN6 |
| PDB (PDBSum) | 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5W4R 5W4V 5X8Q 5YP6 6B30 6BN6 |
| PDB (IMB) | 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5W4R 5W4V 5X8Q 5YP6 6B30 6BN6 |
| Structural Biology KnowledgeBase | 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5W4R 5W4V 5X8Q 5YP6 6B30 6BN6 |
| SCOP (Structural Classification of Proteins) | 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5W4R 5W4V 5X8Q 5YP6 6B30 6BN6 |
| CATH (Classification of proteins structures) | 3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5W4R 5W4V 5X8Q 5YP6 6B30 6BN6 |
| Superfamily | P51449 |
| Human Protein Atlas [tissue] | ENSG00000143365-RORC [tissue] |
| Peptide Atlas | P51449 |
| HPRD | 04250 |
| IPI | IPI00216710 IPI00418178 IPI00909441 IPI00955841 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P51449 |
| IntAct (EBI) | P51449 |
| FunCoup | ENSG00000143365 |
| BioGRID | RORC |
| STRING (EMBL) | RORC |
| ZODIAC | RORC |
| Ontologies - Pathways |
|---|
| QuickGO | P51449 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm transcription initiation from RNA polymerase II promoter xenobiotic metabolic process oxysterol binding oxysterol binding zinc ion binding regulation of glucose metabolic process nuclear body regulation of steroid metabolic process cytokine-mediated signaling pathway intracellular receptor signaling pathway circadian regulation of gene expression cellular response to sterol positive regulation of circadian rhythm steroid hormone mediated signaling pathway regulation of fat cell differentiation positive regulation of transcription, DNA-templated adipose tissue development regulation of transcription involved in cell fate commitment T-helper 17 cell differentiation transcription factor activity, direct ligand regulated sequence-specific DNA binding |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription coactivator binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity steroid hormone receptor activity nuclear receptor activity protein binding nucleus nucleus nucleoplasm transcription initiation from RNA polymerase II promoter xenobiotic metabolic process oxysterol binding oxysterol binding zinc ion binding regulation of glucose metabolic process nuclear body regulation of steroid metabolic process cytokine-mediated signaling pathway intracellular receptor signaling pathway circadian regulation of gene expression cellular response to sterol positive regulation of circadian rhythm steroid hormone mediated signaling pathway regulation of fat cell differentiation positive regulation of transcription, DNA-templated adipose tissue development regulation of transcription involved in cell fate commitment T-helper 17 cell differentiation transcription factor activity, direct ligand regulated sequence-specific DNA binding |
| Pathways : KEGG | Circadian rhythm Inflammatory bowel disease (IBD) |
| NDEx Network | RORC |
| Atlas of Cancer Signalling Network | RORC |
| Wikipedia pathways | RORC |
| Orthology - Evolution |
|---|
| OrthoDB | 6097 |
| GeneTree (enSembl) | ENSG00000143365 |
| Phylogenetic Trees/Animal Genes : TreeFam | RORC |
| HOGENOM | P51449 |
| Homologs : HomoloGene | RORC |
| Homology/Alignments : Family Browser (UCSC) | RORC |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | VPS72/RORC [1q21.3/1q21.3] [t(1;1)(q21;q21)] |
| Fusion Portal | VPS72 1q21.3 RORC 1q21.3 LUAD |
| Fusion : Quiver | RORC |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | RORC [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | RORC |
| dbVar | RORC |
| ClinVar | RORC |
| 1000_Genomes | RORC |
| Exome Variant Server | RORC |
| ExAC (Exome Aggregation Consortium) | ENSG00000143365 |
| GNOMAD Browser | ENSG00000143365 |
| Varsome Browser | RORC |
| Genetic variants : HAPMAP | 6097 |
| Genomic Variants (DGV) | RORC [DGVbeta] |
| DECIPHER | RORC [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | RORC |
| Mutations |
|---|
| ICGC Data Portal | RORC |
| TCGA Data Portal | RORC |
| Broad Tumor Portal | RORC |
| OASIS Portal | RORC [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | RORC [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | RORC |
| Mutations and Diseases : HGMD | RORC |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search RORC |
| DgiDB (Drug Gene Interaction Database) | RORC |
| DoCM (Curated mutations) | RORC (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | RORC (select a term) |
| intoGen | RORC |
| Cancer3D | RORC(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602943 616622 |
| Orphanet | |
| DisGeNET | RORC |
| Medgen | RORC |
| Genetic Testing Registry | RORC
|
| NextProt | P51449 [Medical] |
| TSGene | 6097 |
| GENETests | RORC |
| Target Validation | RORC |
| Huge Navigator |
RORC [HugePedia] |
| snp3D : Map Gene to Disease | 6097 |
| BioCentury BCIQ | RORC |
| ClinGen | RORC |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 6097 |
| Chemical/Pharm GKB Gene | PA34632 |
| Clinical trial | RORC |
| Miscellaneous |
|---|
| canSAR (ICR) | RORC (select the gene name) |
| DataMed Index | RORC |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 122 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | RORC |
| EVEX | RORC |
| GoPubMed | RORC |
| iHOP | RORC |
