RPL34 (ribosomal protein L34)

2003-05-01  

Identity

HGNC
LOCATION
4q25
LOCUSID
ALIAS
L34
FUSION GENES

Other Information

Locus ID:

NCBI: 6164
MIM: 616862
HGNC: 10340
Ensembl: ENSG00000109475

Variants:

dbSNP: 6164
ClinVar: 6164
TCGA: ENSG00000109475
COSMIC: RPL34

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109475ENST00000394665P49207
ENSG00000109475ENST00000394665A0A024RDH8
ENSG00000109475ENST00000394667P49207
ENSG00000109475ENST00000394667A0A024RDH8
ENSG00000109475ENST00000394668P49207
ENSG00000109475ENST00000394668A0A024RDH8
ENSG00000109475ENST00000502534P49207
ENSG00000109475ENST00000502534A0A024RDH8
ENSG00000109475ENST00000506397P49207
ENSG00000109475ENST00000506397A0A024RDH8

Expression (GTEx)

0
500
1000
1500
2000
2500

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
265261352016Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells.12
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
263232422015RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells.8
278458962016Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells.7
278830472016Highly expressed ribosomal protein L34 indicates poor prognosis in osteosarcoma and its knockdown suppresses osteosarcoma proliferation probably through translational control.4
281090792017Silencing of Ribosomal Protein L34 (RPL34) Inhibits the Proliferation and Invasion of Esophageal Cancer Cells.4
286974092017Influence of the RPL34 gene on the growth and metastasis of oral squamous cell carcinoma cells.3
301030682018Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression.2
302165122019Knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway.2

Citation

Dessen P

RPL34 (ribosomal protein L34)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42156/rpl34