RPLP1 (ribosomal protein lateral stalk subunit P1)

2011-03-01 Affiliation

Identity

HGNC

RPLP1

LOCATION

15q23

LOCUSID

6176

ALIAS

LP1,P1,RPP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6176
MIM: 180520
HGNC: 10372
Ensembl: ENSG00000137818

Variants:

dbSNP: 6176
ClinVar: 6176
TCGA: ENSG00000137818
COSMIC: RPLP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137818	ENST00000260379	P05386
ENSG00000137818	ENST00000260379	A0A024R608
ENSG00000137818	ENST00000357790	P05386
ENSG00000137818	ENST00000560274	H0YL57

Expression (GTEx)

500

1000

1500

2000

2500

3000

3500

4000

4500

5000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ribosome	KEGG	ko03010
Ribosome	KEGG	hsa03010
Ribosome, eukaryotes	KEGG	hsa_M00177
Ribosome, eukaryotes	KEGG	M00177
Metabolism of proteins	REACTOME	R-HSA-392499
Translation	REACTOME	R-HSA-72766
Eukaryotic Translation Initiation	REACTOME	R-HSA-72613
Cap-dependent Translation Initiation	REACTOME	R-HSA-72737
Formation of a pool of free 40S subunits	REACTOME	R-HSA-72689
GTP hydrolysis and joining of the 60S ribosomal subunit	REACTOME	R-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expression	REACTOME	R-HSA-156827
SRP-dependent cotranslational protein targeting to membrane	REACTOME	R-HSA-1799339
Eukaryotic Translation Elongation	REACTOME	R-HSA-156842
Peptide chain elongation	REACTOME	R-HSA-156902
Eukaryotic Translation Termination	REACTOME	R-HSA-72764
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Influenza Infection	REACTOME	R-HSA-168254
Influenza Life Cycle	REACTOME	R-HSA-168255
Influenza Viral RNA Transcription and Replication	REACTOME	R-HSA-168273
Viral mRNA Translation	REACTOME	R-HSA-192823
Gene Expression	REACTOME	R-HSA-74160
Nonsense-Mediated Decay (NMD)	REACTOME	R-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	REACTOME	R-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	REACTOME	R-HSA-975956
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Selenoamino acid metabolism	REACTOME	R-HSA-2408522
Selenocysteine synthesis	REACTOME	R-HSA-2408557
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

References

Pubmed ID	Year	Title	Citations
21040949	2011	Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors.	25
18422483	2008	Functional characterization of ribosomal P1/P2 proteins in human cells.	19
22909382	2012	The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.	19
26176264	2015	Disruption of the ribosomal P complex leads to stress-induced autophagy.	12
18675807	2008	Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation.	11
12479870	2003	The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins.	5
23400861	2013	Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.	0

Citation

Dessen P

RPLP1 (ribosomal protein lateral stalk subunit P1)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52108/rplp1