RPP25 (ribonuclease P and MRP subunit p25)

2014-11-01  

Identity

HGNC
LOCATION
15q24.2
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 54913
HGNC: 30361
Ensembl: ENSG00000178718

Variants:

dbSNP: 54913
ClinVar: 54913
TCGA: ENSG00000178718
COSMIC: RPP25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178718ENST00000322177Q9BUL9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA processing in the nucleusREACTOMER-HSA-6784531
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202154412010Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA.22
235870952013Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay.5
206323212010RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder.3
296251992018Crystal Structure of Human Rpp20/Rpp25 Reveals Quaternary Level Adaptation of the Alba Scaffold as Structural Basis for Single-stranded RNA Binding.0

Citation

Dessen P

RPP25 (ribonuclease P and MRP subunit p25)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72843/rpp25