RPRD1A (regulation of nuclear pre-mRNA domain containing 1A)

2021-06-01  

Identity

HGNC
LOCATION
18q12.2
LOCUSID
ALIAS
HsT3101,P15RS

Other Information

Locus ID:

NCBI: 55197
MIM: 610347
HGNC: 25560
Ensembl: ENSG00000141425

Variants:

dbSNP: 55197
ClinVar: 55197
TCGA: ENSG00000141425
COSMIC: RPRD1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141425ENST00000357384Q96P16
ENSG00000141425ENST00000357384A0A024RC37
ENSG00000141425ENST00000399022Q96P16
ENSG00000141425ENST00000399022A0A024RC37
ENSG00000141425ENST00000585953K7EP82
ENSG00000141425ENST00000587563K7ER50
ENSG00000141425ENST00000588737Q96P16
ENSG00000141425ENST00000589050A0A0C4DGQ6
ENSG00000141425ENST00000590898Q96P16
ENSG00000141425ENST00000592674K7EQR8

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
249976002014RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.28
207392732010p15RS attenuates Wnt/{beta}-catenin signaling by disrupting {beta}-catenin·TCF4 Interaction.16
256973592015p15RS/RPRD1A (p15INK4b-related sequence/regulation of nuclear pre-mRNA domain-containing protein 1A) interacts with HDAC2 in inhibition of the Wnt/β-catenin signaling pathway.15
308092862019MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis.10
124706612002Identification and characterization of P15RS, a novel P15(INK4b) related gene on G1/S progression.9
225804562012Cellular and molecular evidence for malignancy-inhibitory functions of p15RS.6

Citation

Dessen P

RPRD1A (regulation of nuclear pre-mRNA domain containing 1A)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58297/rprd1a