RPS15 (ribosomal protein S15)

2003-06-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
RIG,S15
FUSION GENES

Other Information

Locus ID:

NCBI: 6209
MIM: 180535
HGNC: 10388
Ensembl: ENSG00000115268

Variants:

dbSNP: 6209
ClinVar: 6209
TCGA: ENSG00000115268
COSMIC: RPS15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115268ENST00000233609A0A0B4J2B4
ENSG00000115268ENST00000585665K7EM56
ENSG00000115268ENST00000586096K7EJ78
ENSG00000115268ENST00000586656S4R456
ENSG00000115268ENST00000586686K7EM56
ENSG00000115268ENST00000589656K7EQJ5
ENSG00000115268ENST00000591032S4R417
ENSG00000115268ENST00000591804K7EM56
ENSG00000115268ENST00000592588P62841
ENSG00000115268ENST00000592623A0A0B4J2B4
ENSG00000115268ENST00000593052K7ELC2
ENSG00000115268ENST00000617694A0A1Y8EIB3

Expression (GTEx)

0
500
1000
1500

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
247254122014Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease.90
238747132013Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.57
266753462016Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations.46
301811762018Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia.5
318021262020mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site.0
319912152020The functional role of the C-terminal tail of the human ribosomal protein uS19.0

Citation

Dessen P

RPS15 (ribosomal protein S15)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42162/rps15