RPS6KA4 (ribosomal protein S6 kinase A4)

2006-10-01  

Identity

HGNC
RPS6KA4
LOCATION
11q13.1
LOCUSID
8986
ALIAS
MSK2,RSK-B,S6K-alpha-4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8986
MIM: 603606
HGNC: 10433
Ensembl: ENSG00000162302

Variants:

dbSNP: 8986
ClinVar: 8986
TCGA: ENSG00000162302
COSMIC: RPS6KA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162302ENST00000334205O75676
ENSG00000162302ENST00000528057E9PJN1
ENSG00000162302ENST00000528355E9PKU3
ENSG00000162302ENST00000530504A0A0A6YYC0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
208640362010Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.81
174959612007Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.22
208052962011Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.19
261097212015Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection.15
199332782010Differential regulation of mitogen- and stress-activated protein kinase-1 and -2 (MSK1 and MSK2) by CK2 following UV radiation.10
236754622013Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction.6
247924382014Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes.6
213855672011HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2.2
289306102018RPS6KA4/MIR1237 and AURKC promoter regions are differentially methylated in Wilms' tumor.1

Citation

Dessen P

RPS6KA4 (ribosomal protein S6 kinase A4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43479/rps6ka4