RPS6KA5 (ribosomal protein S6 kinase A5)

2006-10-01  

Identity

HGNC
LOCATION
14q32.11
LOCUSID
ALIAS
MSK1,MSPK1,RLPK
FUSION GENES

Other Information

Locus ID:

NCBI: 9252
MIM: 603607
HGNC: 10434
Ensembl: ENSG00000100784

Variants:

dbSNP: 9252
ClinVar: 9252
TCGA: ENSG00000100784
COSMIC: RPS6KA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100784ENST00000554206G3V2D1
ENSG00000100784ENST00000556178H0YJE1
ENSG00000100784ENST00000556594G3V4D7
ENSG00000100784ENST00000614987O75582
ENSG00000100784ENST00000648062A0A3B3ISL8

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Bladder cancerKEGGko05219
MAPK signaling pathwayKEGGhsa04010
Bladder cancerKEGGhsa05219
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 10 (TLR10) CascadeREACTOMER-HSA-168142
MyD88 cascade initiated on plasma membraneREACTOMER-HSA-975871
MAP kinase activation in TLR cascadeREACTOMER-HSA-450294
MAPK targets/ Nuclear events mediated by MAP kinasesREACTOMER-HSA-450282
ERK/MAPK targetsREACTOMER-HSA-198753
CREB phosphorylationREACTOMER-HSA-199920
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
Toll Like Receptor 5 (TLR5) CascadeREACTOMER-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) CascadeREACTOMER-HSA-168181
MyD88 dependent cascade initiated on endosomeREACTOMER-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationREACTOMER-HSA-975138
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
MyD88:Mal cascade initiated on plasma membraneREACTOMER-HSA-166058
Toll Like Receptor 2 (TLR2) CascadeREACTOMER-HSA-181438
Toll Like Receptor TLR1:TLR2 CascadeREACTOMER-HSA-168179
Toll Like Receptor TLR6:TLR2 CascadeREACTOMER-HSA-168188
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
CD209 (DC-SIGN) signalingREACTOMER-HSA-5621575
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Nuclear Events (kinase and transcription factor activation)REACTOMER-HSA-198725
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208640362010Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.81
212826602011Histone code pathway involving H3 S28 phosphorylation and K27 acetylation activates transcription and antagonizes polycomb silencing.66
204068062010MiR-148a attenuates paclitaxel resistance of hormone-refractory, drug-resistant prostate cancer PC3 cells by regulating MSK1 expression.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
126901132003Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells.61
191973682009Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation.56
197067152009Respiratory syncytial virus infection induces a reactive oxygen species-MSK1-phospho-Ser-276 RelA pathway required for cytokine expression.49
167629162006Activation of the mitogen- and stress-activated kinase 1 by arsenic trioxide.30
201983392010Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.27
184244382008NF-kappaB-dependent transcriptional activation in lung carcinoma cells by farnesol involves p65/RelA(Ser276) phosphorylation via the MEK-MSK1 signaling pathway.25

Citation

Dessen P

RPS6KA5 (ribosomal protein S6 kinase A5)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43480/rps6ka5