RPSA (ribosomal protein SA)

2003-06-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
37LRP,67LR,ICAS,LAMBR,LAMR1,LBP,LBP/p40,LRP,LRP/LR,NEM/1CHD4,SA,lamR,p40
FUSION GENES

Other Information

Locus ID:

NCBI: 3921
MIM: 150370
HGNC: 6502
Ensembl: ENSG00000168028

Variants:

dbSNP: 3921
ClinVar: 3921
TCGA: ENSG00000168028
COSMIC: RPSA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168028ENST00000301821P08865
ENSG00000168028ENST00000301821A0A024R2P0
ENSG00000168028ENST00000443003A0A0C4DG17
ENSG00000168028ENST00000444512F8WD59
ENSG00000168028ENST00000458478C9J9K3

Expression (GTEx)

0
500
1000
1500
2000
2500

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169735872006The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9.158
235794972013Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia.75
192248612009Laminin receptor involvement in the anti-angiogenic activity of pigment epithelium-derived factor.63
187945472008Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.61
15516338200567-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells.55
182693482008The 67 kDa laminin receptor: structure, function and role in disease.55
180791192008Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor.50
23348740201367-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis.46
212431002010Extraribosomal functions associated with the C terminus of the 37/67 kDa laminin receptor are required for maintaining cell viability.24
205157472010Interactions between PrP(c) and other ligands with the 37-kDa/67-kDa laminin receptor.17

Citation

Dessen P

RPSA (ribosomal protein SA)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41124/rpsa