RTKN (rhotekin)

2007-02-01  

Identity

HGNC
LOCATION
2p13.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 6242
MIM: 602288
HGNC: 10466
Ensembl: ENSG00000114993

Variants:

dbSNP: 6242
ClinVar: 6242
TCGA: ENSG00000114993
COSMIC: RTKN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114993ENST00000233330Q9BST9
ENSG00000114993ENST00000272430Q9BST9
ENSG00000114993ENST00000305557Q9BST9
ENSG00000114993ENST00000640304A0A1W2PPZ2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate Rhotekin and RhophilinsREACTOMER-HSA-5666185

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193603602009miR-145 inhibits breast cancer cell growth through RTKN.60
154804282004Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis.26
229646352013Coupling S100A4 to Rhotekin alters Rho signaling output in breast cancer cells.22
175466472007SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.14
192944872009Interaction of a multi-domain adaptor protein, vinexin, with a Rho-effector, Rhotekin.14
222287652012Protein kinase D regulates RhoA activity via rhotekin phosphorylation.14
169797702006Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.13
274980322016Let-7a inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer.8
153161422004Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma.7
279226902017MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma.7

Citation

Dessen P

RTKN (rhotekin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43808/rtkn