RTN1 (reticulon 1)

2003-11-01  

Identity

HGNC
LOCATION
14q23.1
LOCUSID
ALIAS
NSP
FUSION GENES

Other Information

Locus ID:

NCBI: 6252
MIM: 600865
HGNC: 10467
Ensembl: ENSG00000139970

Variants:

dbSNP: 6252
ClinVar: 6252
TCGA: ENSG00000139970
COSMIC: RTN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139970ENST00000267484Q16799
ENSG00000139970ENST00000342503Q16799
ENSG00000139970ENST00000395090A8MT72
ENSG00000139970ENST00000611068Q2NKQ5

Expression (GTEx)

0
100
200
300
400
500
600
700

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
166020182006Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein.23
262274932015RTN1 mediates progression of kidney disease by inducing ER stress.21
287608232017Ascorbate peroxidase proximity labeling coupled with biochemical fractionation identifies promoters of endoplasmic reticulum-mitochondrial contacts.20
175962102007Reticulon-1C acts as a molecular switch between endoplasmic reticulum stress and genotoxic cell death pathway in human neuroblastoma cells.15
196682292009Acetylation of RTN-1C regulates the induction of ER stress by the inhibition of HDAC activity in neuroectodermal tumors.14
149950772003Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex.12
235590152013Reticulon1-C modulates protein disulphide isomerase function.11
267398912016Knockdown of RTN1A attenuates ER stress and kidney injury in albumin overload-induced nephropathy.9
191406932009Nucleic acid binding of the RTN1-C C-terminal region: toward the functional role of a reticulon protein.6

Citation

Dessen P

RTN1 (reticulon 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42181/rtn1