RUBCN (rubicon autophagy regulator)

2016-01-01  

Identity

HGNC
RUBCN
LOCATION
3q29
LOCUSID
9711
ALIAS
KIAA0226,RUBICON,SCAR15
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9711
MIM: 613516
HGNC: 28991
Ensembl: ENSG00000145016

Variants:

dbSNP: 9711
ClinVar: 9711
TCGA: ENSG00000145016
COSMIC: RUBCN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145016ENST00000273582Q92622
ENSG00000145016ENST00000296343Q92622
ENSG00000145016ENST00000413360H0Y6E6
ENSG00000145016ENST00000415452H7C357
ENSG00000145016ENST00000447048H7C3H3
ENSG00000145016ENST00000449205E9PEM3
ENSG00000145016ENST00000474214A0A096LNI3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192706962009Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.443
209749682010Rubicon controls endosome maturation as a Rab7 effector.93
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
224239662012Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation.50
210627452011The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression.49
209439502010Rubicon and PLEKHM1 negatively regulate the endocytic/autophagic pathway via a novel Rab7-binding domain.40
258071082015HCV induces the expression of Rubicon and UVRAG to temporally regulate the maturation of autophagosomes and viral replication.40
224239672012The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity.31
225276812012Recent advances in the genetics of cerebellar ataxias.26
292157972018Rubicon: LC3-associated phagocytosis and beyond.16

Citation

Dessen P

RUBCN (rubicon autophagy regulator)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/77965/rubcn