RWDD3 (RWD domain containing 3)

2009-08-01  

Identity

HGNC
LOCATION
1p21.3
LOCUSID
ALIAS
RSUME
FUSION GENES

Other Information

Locus ID:

NCBI: 25950
MIM: 615875
HGNC: 21393
Ensembl: ENSG00000122481

Variants:

dbSNP: 25950
ClinVar: 25950
TCGA: ENSG00000122481
COSMIC: RWDD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122481ENST00000263893Q9Y3V2
ENSG00000122481ENST00000370202Q9Y3V2

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is transferred from E1 to E2 (UBE2I, UBC9)REACTOMER-HSA-3065678

References

Pubmed IDYearTitleCitations
179567322007RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.96
235081082013RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.18
220097972012RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells.13
228772412013GWAS-based association between RWDD3 and TECTA variants and paclitaxel induced neuropathy could not be confirmed in Scandinavian ovarian cancer patients.13
255005452015RSUME inhibits VHL and regulates its tumor suppressor function.8
279897712017Relationship between RSUME and HIF-1α/VEGF-A with invasion of pituitary adenoma.8
255495362015RWDD3 and TECTA variants not linked to paclitaxel induced peripheral neuropathy in North American trial Alliance N08C1.5
194075042009Differential gene expression in models of pituitary prolactin-producing tumoral cells.4
234690692013In silico structural and functional characterization of the RSUME splice variants.4
262978262015Role of RSUME in inflammation and cancer.4

Citation

Dessen P

RWDD3 (RWD domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51010/rwdd3