RXFP1 (relaxin family peptide receptor 1)

2009-05-01  

Identity

HGNC
LOCATION
4q32.1
LOCUSID
ALIAS
LGR7,RXFPR1
FUSION GENES

Other Information

Locus ID:

NCBI: 59350
MIM: 606654
HGNC: 19718
Ensembl: ENSG00000171509

Variants:

dbSNP: 59350
ClinVar: 59350
TCGA: ENSG00000171509
COSMIC: RXFP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171509ENST00000307765Q9HBX9
ENSG00000171509ENST00000342048E9PIF0
ENSG00000171509ENST00000343542Q9HBX9
ENSG00000171509ENST00000423548B4DGP2
ENSG00000171509ENST00000448688A0A0A0MT52
ENSG00000171509ENST00000460056E9PCA3
ENSG00000171509ENST00000470033Q9HBX9
ENSG00000171509ENST00000471616Q9HBX9
ENSG00000171509ENST00000613319A0A087WWV0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
118099712002Activation of orphan receptors by the hormone relaxin.144
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
169634512006Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.42
206645202010Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex.33
154659252005Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.26
184343062008The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.26
156955052005The trap-like relaxin-binding site of the leucine-rich G-protein-coupled receptor 7.23
171484552007The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation.19
171582032007The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane.18
180791952008Cloning, expression, and functional characterization of relaxin receptor (leucine-rich repeat-containing g protein-coupled receptor 7) splice variants from human fetal membranes.18

Citation

Dessen P

RXFP1 (relaxin family peptide receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50924/rxfp1