RXFP2 (relaxin family peptide receptor 2)

2011-09-01  

Identity

HGNC
LOCATION
13q13.1
LOCUSID
ALIAS
GPR106,GREAT,INSL3R,LGR8,LGR8.1,RXFPR2

Other Information

Locus ID:

NCBI: 122042
MIM: 606655
HGNC: 17318
Ensembl: ENSG00000133105

Variants:

dbSNP: 122042
ClinVar: 122042
TCGA: ENSG00000133105
COSMIC: RXFP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133105ENST00000298386Q8WXD0
ENSG00000133105ENST00000380314Q8WXD0

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
169634512006Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules.42
190179132008Genetic alterations associated with cryptorchidism.29
184343062008The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.26
169263832007T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane.19
229730492012The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2.18
157088462005LGR8 signal activation by the relaxin-like factor.16
168679802006Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.16
174732812007Defining the LGR8 residues involved in binding insulin-like peptide 3.15
194161882009INSL3/RXFP2 signaling in testicular descent.15
160516772005Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity.14

Citation

Dessen P

RXFP2 (relaxin family peptide receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52389/rxfp2