RXFP3 (relaxin family peptide receptor 3)

2010-05-01  

Identity

HGNC
LOCATION
5p13.2
LOCUSID
ALIAS
GPCR135,RLN3R1,RXFPR3,SALPR

Other Information

Locus ID:

NCBI: 51289
MIM: 609445
HGNC: 24883
Ensembl: ENSG00000182631

Variants:

dbSNP: 51289
ClinVar: 51289
TCGA: ENSG00000182631
COSMIC: RXFP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182631ENST00000330120Q9NSD7

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145229682003Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.56
154659252005Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.26
184343062008The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors.26
201599432010H2 relaxin is a biased ligand relative to H3 relaxin at the relaxin family peptide receptor 3 (RXFP3).9
202114852010Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.8
159567302005Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.7
246415482014Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).6
191526342009The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.5
246152372014The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3.5
274980382016Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.5

Citation

Dessen P

RXFP3 (relaxin family peptide receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51451/rxfp3