RXFP3 (relaxin family peptide receptor 3)

2010-05-01  

Identity

HGNC
LOCATION
5p13.2
LOCUSID
ALIAS
GPCR135,RLN3R1,RXFPR3,SALPR

Other Information

Locus ID:

NCBI: 51289
MIM: 609445
HGNC: 24883
Ensembl: ENSG00000182631

Variants:

dbSNP: 51289
ClinVar: 51289
TCGA: ENSG00000182631
COSMIC: RXFP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182631ENST00000330120Q9NSD7

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Relaxin receptorsREACTOMER-HSA-444821
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379670732023Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.0
379670732023Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric disorders and metabolic phenotypes: A candidate gene approach.0
345372632021The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review.3
345372632021The putative role of the relaxin-3/RXFP3 system in clinical depression and anxiety: A systematic literature review.3
328105652020Hydrophobic interactions of relaxin family peptide receptor 3 with ligands identified using a NanoBiT-based binding assay.0
328105652020Hydrophobic interactions of relaxin family peptide receptor 3 with ligands identified using a NanoBiT-based binding assay.0
306844582019Exploring electrostatic interactions of relaxin family peptide receptor 3 and 4 with ligands using a NanoBiT-based binding assay.1
306844582019Exploring electrostatic interactions of relaxin family peptide receptor 3 and 4 with ligands using a NanoBiT-based binding assay.1
291598322018Expression and localisation of RXFP3 in human spermatozoa and impact of INSL7 on sperm functions.3
291598322018Expression and localisation of RXFP3 in human spermatozoa and impact of INSL7 on sperm functions.3
273532812016A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.1
274043932016Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.5
274980382016Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.7
273532812016A negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3.1
274043932016Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.5

Citation

Dessen P

RXFP3 (relaxin family peptide receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51451/rxfp3