RXFP4 (relaxin family peptide/INSL5 receptor 4)

2014-11-01 Affiliation

Identity

HGNC

RXFP4

LOCATION

1q22

LOCUSID

339403

ALIAS

GPCR142,GPR100,RLN3R2,RXFPR4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 339403
MIM: 609043
HGNC: 14666
Ensembl: ENSG00000173080

Variants:

dbSNP: 339403
ClinVar: 339403
TCGA: ENSG00000173080
COSMIC: RXFP4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000173080	ENST00000368318	Q8TDU9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Relaxin receptors	REACTOME	R-HSA-444821
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
14522967	2003	Identification of relaxin-3/INSL7 as a ligand for GPCR142.	35
15525639	2005	INSL5 is a high affinity specific agonist for GPCR142 (GPR100).	32
15465925	2005	Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.	26
24802387	2014	The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation.	3
25043977	2014	Identification of important residues of insulin-like peptide 5 and its receptor RXFP4 for ligand-receptor interactions.	3
26661035	2016	The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.	3
27404393	2016	Mechanism for insulin-like peptide 5 distinguishing the homologous relaxin family peptide receptor 3 and 4.	3
18582868	2008	Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135).	2
28274616	2017	Interaction mechanism of insulin-like peptide 5 with relaxin family peptide receptor 4.	2
27888281	2017	The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.	1

Citation

Dessen P

RXFP4 (relaxin family peptide/INSL5 receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/72947/rxfp4