SAP18 (Sin3A associated protein 18)

2003-05-01  

Identity

HGNC
SAP18
LOCATION
13q12.11
LOCUSID
10284
ALIAS
2HOR0202,SAP18P
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10284
MIM: 602949
HGNC: 10530
Ensembl: ENSG00000150459

Variants:

dbSNP: 10284
ClinVar: 10284
TCGA: ENSG00000150459
COSMIC: SAP18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150459ENST00000382533O00422
ENSG00000150459ENST00000450573H7BZW6
ENSG00000150459ENST00000467636U3KPY7
ENSG00000150459ENST00000492245U3KQ12
ENSG00000150459ENST00000607003O00422
ENSG00000150459ENST00000607003A0A384ME24
ENSG00000150459ENST00000621421O00422

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Exon junction complex (EJC)KEGGhsa_M00430
Exon junction complex (EJC)KEGGM00430
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195036032009Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication.27
209661982010Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold.17
259213042015Sin3A-associated protein, 18 kDa, a novel binding partner of TRIB1, regulates MTTP expression.10

Citation

Dessen P

SAP18 (Sin3A associated protein 18)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42201/sap18