SARAF (store-operated calcium entry associated regulatory factor)

2014-06-01 Affiliation

Identity

HGNC

SARAF

LOCATION

8p12

LOCUSID

51669

ALIAS

FOAP-7,HSPC035,TMEM66,XTP3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51669
MIM: 614768
HGNC: 28789
Ensembl: ENSG00000133872

Variants:

dbSNP: 51669
ClinVar: 51669
TCGA: ENSG00000133872
COSMIC: SARAF

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133872	ENST00000256255	Q96BY9
ENSG00000133872	ENST00000256255	A0A140VK59
ENSG00000133872	ENST00000518174	E5RK07
ENSG00000133872	ENST00000518296	H0YAN9
ENSG00000133872	ENST00000518340	E5RJV6
ENSG00000133872	ENST00000520303	E5RJV6
ENSG00000133872	ENST00000521265	H0YBH7
ENSG00000133872	ENST00000522055	E5RJG8
ENSG00000133872	ENST00000522794	E5RHW0
ENSG00000133872	ENST00000523127	H0YAZ1
ENSG00000133872	ENST00000523761	E5RFJ9
ENSG00000133872	ENST00000545648	Q96BY9

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
22464749	2012	SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
23049731	2012	Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients.	52
23816623	2013	The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function.	32
27068144	2016	Dynamic interaction of SARAF with STIM1 and Orai1 to modulate store-operated calcium entry.	11
26817842	2016	Store-operated Ca2+ Entry-associated Regulatory factor (SARAF) Plays an Important Role in the Regulation of Arachidonate-regulated Ca2+ (ARC) Channels.	9
27506849	2016	SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner.	5
29223474	2018	Fine-tuning of store-operated calcium entry by fast and slow Ca²⁺-dependent inactivation: Involvement of SARAF.	5
30481768	2018	EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction.	4
28866365	2017	Store-operated calcium entry is dispensable for the activation of ERK1/2 pathway in prostate cancer cells.	3

Citation

Dessen P

SARAF (store-operated calcium entry associated regulatory factor)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54028/saraf