SART3 (spliceosome associated factor 3, U4/U6 recycling protein)

2003-06-01  

Identity

HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
DSAP1,P100,RP11-13G14,TIP110,p110,p110(nrb)
FUSION GENES

Other Information

Locus ID:

NCBI: 9733
MIM: 611684
HGNC: 16860
Ensembl: ENSG00000075856

Variants:

dbSNP: 9733
ClinVar: 9733
TCGA: ENSG00000075856
COSMIC: SART3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075856ENST00000228284A0A499FI31
ENSG00000075856ENST00000431469Q15020
ENSG00000075856ENST00000546611Q15020
ENSG00000075856ENST00000546728Q15020
ENSG00000075856ENST00000546815Q15020
ENSG00000075856ENST00000547397H0YHU8
ENSG00000075856ENST00000547528F8W667
ENSG00000075856ENST00000550322F8VZM2
ENSG00000075856ENST00000550619F8VVK9
ENSG00000075856ENST00000651280A0A494C0L2

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125789092003Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies.53
245266892014The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination.35
153141512004Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling.25
1856781220083'-cyclic phosphorylation of U6 snRNA leads to recruitment of recycling factor p110 through LSm proteins.25
221329412012Tip110 maintains expression of pluripotent factors in and pluripotency of human embryonic stem cells.13
150312862004Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation.12
147493852004Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP.11
230883992013C-MYC controlled TIP110 protein expression regulates OCT4 mRNA splicing in human embryonic stem cells.11
270601352016Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3.10
119205222002Expression of tumor rejection antigens in colorectal carcinomas.9

Citation

Dessen P

SART3 (spliceosome associated factor 3, U4/U6 recycling protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42205/sart3