SCD5 (stearoyl-CoA desaturase 5)

2015-09-01  

Identity

HGNC
LOCATION
4q21.22
LOCUSID
ALIAS
ACOD4,DFNA79,FADS4,HSCD5,SCD2,SCD4
FUSION GENES

Other Information

Locus ID:

NCBI: 79966
MIM: 608370
HGNC: 21088
Ensembl: ENSG00000145284

Variants:

dbSNP: 79966
ClinVar: 79966
TCGA: ENSG00000145284
COSMIC: SCD5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145284ENST00000273908Q86SK9
ENSG00000145284ENST00000319540Q86SK9

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Biosynthesis of unsaturated fatty acidsKEGGko01040
PPAR signaling pathwayKEGGko03320
Biosynthesis of unsaturated fatty acidsKEGGhsa01040
PPAR signaling pathwayKEGGhsa03320
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
128150402003Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors.30
238677972013Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2.20
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
174688872007Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5.15
227458282012StearoylCoA desaturase-5: a novel regulator of neuronal cell proliferation and differentiation.13
156100692005Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
258022342015SCD5-induced oleic acid production reduces melanoma malignancy by intracellular retention of SPARC and cathepsin B.8

Citation

Dessen P

SCD5 (stearoyl-CoA desaturase 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55387/scd5