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SCGN (secretagogin, EF-hand calcium binding protein)

Identity

Alias_symbol (synonym)SECRET
DJ501N12.8
SEGN
CALBL
Other aliassetagin
HGNC (Hugo) SCGN
LocusID (NCBI) 10590
Atlas_Id 45603
Location 6p22.2  [Link to chromosome band 6p22]
Location_base_pair Starts at 25652215 and ends at 25701780 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTN1 (14q24.1) / SCGN (6p22.2)GAS5 (1q25.1) / SCGN (6p22.2)ACTN1 14q24.1 / SCGN 6p22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;14)(p22;q24) ACTN1/SCGN

External links

Nomenclature
HGNC (Hugo)SCGN   16941
Cards
Entrez_Gene (NCBI)SCGN  10590  secretagogin, EF-hand calcium binding protein
AliasesCALBL; DJ501N12.8; SECRET; SEGN; 
setagin
GeneCards (Weizmann)SCGN
Ensembl hg19 (Hinxton)ENSG00000079689 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000079689 [Gene_View]  ENSG00000079689 [Sequence]  chr6:25652215-25701780 [Contig_View]  SCGN [Vega]
ICGC DataPortalENSG00000079689
TCGA cBioPortalSCGN
AceView (NCBI)SCGN
Genatlas (Paris)SCGN
WikiGenes10590
SOURCE (Princeton)SCGN
Genetics Home Reference (NIH)SCGN
Genomic and cartography
GoldenPath hg38 (UCSC)SCGN  -     chr6:25652215-25701780 +  6p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SCGN  -     6p22.2   [Description]    (hg19-Feb_2009)
GoldenPathSCGN - 6p22.2 [CytoView hg19]  SCGN - 6p22.2 [CytoView hg38]
ImmunoBaseENSG00000079689
genome Data Viewer NCBISCGN [Mapview hg19]  
OMIM609202   
Gene and transcription
Genbank (Entrez)AF420280 AK094387 AK289477 BC000336 BC003036
RefSeq transcript (Entrez)NM_006998
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SCGN
Alternative Splicing GalleryENSG00000079689
Gene ExpressionSCGN [ NCBI-GEO ]   SCGN [ EBI - ARRAY_EXPRESS ]   SCGN [ SEEK ]   SCGN [ MEM ]
Gene Expression Viewer (FireBrowse)SCGN [ Firebrowse - Broad ]
GenevisibleExpression of SCGN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10590
GTEX Portal (Tissue expression)SCGN
Human Protein AtlasENSG00000079689-SCGN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76038   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76038  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76038
Splice isoforms : SwissVarO76038
PhosPhoSitePlusO76038
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    EFh_SCGN   
Domain families : Pfam (Sanger)EF-hand_5 (PF13202)    EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13202    pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)SCGN
DMDM Disease mutations10590
Blocks (Seattle)SCGN
SuperfamilyO76038
Human Protein Atlas [tissue]ENSG00000079689-SCGN [tissue]
Peptide AtlasO76038
HPRD10211
IPIIPI00008730   IPI00044168   
Protein Interaction databases
DIP (DOE-UCLA)O76038
IntAct (EBI)O76038
FunCoupENSG00000079689
BioGRIDSCGN
STRING (EMBL)SCGN
ZODIACSCGN
Ontologies - Pathways
QuickGOO76038
Ontology : AmiGOcalcium ion binding  calcium ion binding  extracellular region  nucleus  cytoplasm  cytosol  biological_process  dendrite  transport vesicle membrane  neuron projection  terminal bouton  synapse  regulation of cytosolic calcium ion concentration  regulation of presynaptic cytosolic calcium ion concentration  regulation of long-term synaptic potentiation  
Ontology : EGO-EBIcalcium ion binding  calcium ion binding  extracellular region  nucleus  cytoplasm  cytosol  biological_process  dendrite  transport vesicle membrane  neuron projection  terminal bouton  synapse  regulation of cytosolic calcium ion concentration  regulation of presynaptic cytosolic calcium ion concentration  regulation of long-term synaptic potentiation  
NDEx NetworkSCGN
Atlas of Cancer Signalling NetworkSCGN
Wikipedia pathwaysSCGN
Orthology - Evolution
OrthoDB10590
GeneTree (enSembl)ENSG00000079689
Phylogenetic Trees/Animal Genes : TreeFamSCGN
HOGENOMO76038
Homologs : HomoloGeneSCGN
Homology/Alignments : Family Browser (UCSC)SCGN
Gene fusions - Rearrangements
Fusion : MitelmanACTN1/SCGN [14q24.1/6p22.2]  
Fusion PortalACTN1 14q24.1 SCGN 6p22.2 BRCA
Fusion : QuiverSCGN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSCGN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SCGN
dbVarSCGN
ClinVarSCGN
1000_GenomesSCGN 
Exome Variant ServerSCGN
GNOMAD BrowserENSG00000079689
Varsome BrowserSCGN
Genetic variants : HAPMAP10590
Genomic Variants (DGV)SCGN [DGVbeta]
DECIPHERSCGN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSCGN 
Mutations
ICGC Data PortalSCGN 
TCGA Data PortalSCGN 
Broad Tumor PortalSCGN
OASIS PortalSCGN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSCGN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSCGN
Mutations and Diseases : HGMDSCGN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SCGN
DgiDB (Drug Gene Interaction Database)SCGN
DoCM (Curated mutations)SCGN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SCGN (select a term)
intoGenSCGN
Cancer3DSCGN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609202   
Orphanet
DisGeNETSCGN
MedgenSCGN
Genetic Testing Registry SCGN
NextProtO76038 [Medical]
TSGene10590
GENETestsSCGN
Target ValidationSCGN
Huge Navigator SCGN [HugePedia]
snp3D : Map Gene to Disease10590
BioCentury BCIQSCGN
ClinGenSCGN
Clinical trials, drugs, therapy
Protein Interactions : CTD10590
Pharm GKB GenePA38428
Clinical trialSCGN
Miscellaneous
canSAR (ICR)SCGN (select the gene name)
HarmonizomeSCGN
DataMed IndexSCGN
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSCGN
EVEXSCGN
GoPubMedSCGN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jul 10 19:39:42 CEST 2020
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