SCIN (scinderin)

2014-03-01  

Identity

HGNC
LOCATION
7p21.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 85477
MIM: 613416
HGNC: 21695
Ensembl: ENSG00000006747

Variants:

dbSNP: 85477
ClinVar: 85477
TCGA: ENSG00000006747
COSMIC: SCIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006747ENST00000297029Q9Y6U3
ENSG00000006747ENST00000341757Q9Y6U3
ENSG00000006747ENST00000417018C9JGB6
ENSG00000006747ENST00000436854F8WBX5
ENSG00000006747ENST00000518849E5RHN8
ENSG00000006747ENST00000519209Q9Y6U3
ENSG00000006747ENST00000523729E5RHX6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
270334552016Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.18
242129162014Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest.16
196665312009The crystal structure of the C-terminus of adseverin reveals the actin-binding interface.13
253038732015Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells.9
243304982013Expression of EPHRIN-A1, SCINDERIN and MHC class I molecules in head and neck cancers and relationship with the prognostic value of intratumoral CD8+ T cells.8
251744062014Suppression of scinderin modulates epithelial‑mesenchymal transition markers in highly metastatic gastric cancer cell line SGC‑7901.6
273476592016A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.4
294576582018Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia.3
282131292017Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.2
312049122019[Clinical Study of SCIN Expression and Dromoter Methylation in Patients with Chronic Myeloid Leukemia].0

Citation

Dessen P

SCIN (scinderin)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53852/scin