SCLY (selenocysteine lyase)

2007-02-01  

Identity

HGNC
SCLY
LOCATION
2q37.3
LOCUSID
51540
ALIAS
SCL,hSCL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51540
MIM: 611056
HGNC: 18161
Ensembl: ENSG00000132330

Variants:

dbSNP: 51540
ClinVar: 51540
TCGA: ENSG00000132330
COSMIC: SCLY

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132330ENST00000254663Q96I15
ENSG00000132330ENST00000409736Q96I15
ENSG00000132330ENST00000412508H7C4A1
ENSG00000132330ENST00000413463C9JNL5
ENSG00000132330ENST00000416757H7C280
ENSG00000132330ENST00000423324F8WCL3
ENSG00000132330ENST00000433750H7C1N7
ENSG00000132330ENST00000437134H7C277
ENSG00000132330ENST00000440143H7C2H3
ENSG00000132330ENST00000443532H7C2M1
ENSG00000132330ENST00000446202F8WBU3
ENSG00000132330ENST00000450965H7C3V9
ENSG00000132330ENST00000651534A0A0A0MQU4

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Selenocompound metabolismKEGGko00450
Selenocompound metabolismKEGGhsa00450
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested SeMet, Sec, MeSec into H2SeREACTOMER-HSA-2408508

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
106924122000cDNA cloning, purification, and characterization of mouse liver selenocysteine lyase. Candidate for selenium delivery protein in selenoprotein synthesis.24
222950932012Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.9
222919782012Biochemical discrimination between selenium and sulfur 2: mechanistic investigation of the selenium specificity of human selenocysteine lyase.3
169250922006[Differential display of messenger RNA and identification of selenocysteine lyase gene in hepatocellular carcinoma cells transiently expressing hepatitis C virus core protein].1

Citation

Dessen P

SCLY (selenocysteine lyase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46490/scly