SCN3B (sodium voltage-gated channel beta subunit 3)

2007-02-01  

Identity

HGNC
LOCATION
11q24.1
LOCUSID
ALIAS
ATFB16,BRGDA7,HSA243396,SCNB3

Other Information

Locus ID:

NCBI: 55800
MIM: 608214
HGNC: 20665
Ensembl: ENSG00000166257

Variants:

dbSNP: 55800
ClinVar: 55800
TCGA: ENSG00000166257
COSMIC: SCN3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166257ENST00000299333Q9NY72
ENSG00000166257ENST00000299333A0A024R3H7
ENSG00000166257ENST00000392770Q9NY72
ENSG00000166257ENST00000392770A0A024R3H7
ENSG00000166257ENST00000530277Q9NY72
ENSG00000166257ENST00000530277A0A024R3H7
ENSG00000166257ENST00000657123Q9NY72
ENSG00000166257ENST00000657123A0A024R3H7
ENSG00000166257ENST00000657191Q9NY72
ENSG00000166257ENST00000657191A0A024R3H7
ENSG00000166257ENST00000659826A0A590UJQ5
ENSG00000166257ENST00000667790A0A590UJ13

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Interaction between L1 and AnkyrinsREACTOMER-HSA-445095
Cardiac conductionREACTOMER-HSA-5576891
Phase 0 - rapid depolarisationREACTOMER-HSA-5576892

References

Pubmed IDYearTitleCitations
316267142020Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.3
316267142020Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation.3
303008962018An Analysis of the Association between Epilepsy-Related Genes and Vertigo in the Polish Population.0
303008962018An Analysis of the Association between Epilepsy-Related Genes and Vertigo in the Polish Population.0
257576622015The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.13
261798112015Contribution of Cardiac Sodium Channel β-Subunit Variants to Brugada Syndrome.4
257576622015The role of the sodium current complex in a nonreferred nationwide cohort of sudden infant death syndrome.13
261798112015Contribution of Cardiac Sodium Channel β-Subunit Variants to Brugada Syndrome.4
254432312014Risk factors and genetics of atrial fibrillation.9
254432312014Risk factors and genetics of atrial fibrillation.9
231180272013The immunoglobulin domain of the sodium channel β3 subunit contains a surface-localized disulfide bond that is required for homophilic binding.20
232573892013Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5.41
231180272013The immunoglobulin domain of the sodium channel β3 subunit contains a surface-localized disulfide bond that is required for homophilic binding.20
232573892013Novel SCN3B mutation associated with brugada syndrome affects intracellular trafficking and function of Nav1.5.41
210514192011Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation.52

Citation

Dessen P

SCN3B (sodium voltage-gated channel beta subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45847/scn3b