SCN4B (sodium voltage-gated channel beta subunit 4)

2018-11-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
ATFB17,LQT10,Navbeta4
FUSION GENES

Other Information

Locus ID:

NCBI: 6330
MIM: 608256
HGNC: 10592
Ensembl: ENSG00000177098

Variants:

dbSNP: 6330
ClinVar: 6330
TCGA: ENSG00000177098
COSMIC: SCN4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177098ENST00000324727Q8IWT1
ENSG00000177098ENST00000324727B0YJ93
ENSG00000177098ENST00000529878Q8IWT1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Muscle contractionREACTOMER-HSA-397014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Interaction between L1 and AnkyrinsREACTOMER-HSA-445095
Cardiac conductionREACTOMER-HSA-5576891
Phase 0 - rapid depolarisationREACTOMER-HSA-5576892

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
129307962003Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.139
175920812007SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome.106
198084772009Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation.70
198084772009Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation.70
301903092018Structure of the human voltage-gated sodium channel Na<sub>v</sub>1.4 in complex with β1.49
254502272015Transcriptome organization for chronic alcohol abuse in human brain.46
242979192013Crystallographic insights into sodium-channel modulation by the β4 subunit.42
211156382011Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents.40
210514192011Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation.39
228423452012A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells.37

Citation

Dessen P

SCN4B (sodium voltage-gated channel beta subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57725/scn4b