SCO2 (synthesis of cytochrome C oxidase 2)

2007-04-01  

Identity

HGNC
SCO2
LOCATION
22q13.33
LOCUSID
9997
ALIAS
CEMCOX1,ECGF1,Gliostatin,MC4DN2,MYP6,PD-ECGF,SCO1L,TP,TYMP,TdRPase
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9997
MIM: 604272
HGNC: 10604
Ensembl: ENSG00000284194

Variants:

dbSNP: 9997
ClinVar: 9997
TCGA: ENSG00000284194
COSMIC: SCO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000284194ENST00000252785O43819
ENSG00000284194ENST00000395693O43819
ENSG00000284194ENST00000535425O43819
ENSG00000284194ENST00000543927O43819
ENSG00000284194ENST00000638598A0A1W2PQK0

Pathways

PathwaySourceExternal ID
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Respiratory electron transportREACTOMER-HSA-611105

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
343696242021TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation.10
343696242021TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation.10
316173812020Systemic Mitochondrial Oxidative Phosphorylation Protein Levels Correlate with Neuroimaging Measures in Chronically HIV-Infected Individuals.7
316173812020Systemic Mitochondrial Oxidative Phosphorylation Protein Levels Correlate with Neuroimaging Measures in Chronically HIV-Infected Individuals.7
296349762018High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma.12
296349762018High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma.12
266763732016SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.15
270524452016Association between SCO2 mutation and extreme myopia in Japanese patients.8
274991522016Distinctive interrelation of p53 with SCO2, COX, and TIGAR in human gastric cancer.14
266763732016SCO2 Mediates Oxidative Stress-Induced Glycolysis to Oxidative Phosphorylation Switch in Hematopoietic Stem Cells.15
270524452016Association between SCO2 mutation and extreme myopia in Japanese patients.8
274991522016Distinctive interrelation of p53 with SCO2, COX, and TIGAR in human gastric cancer.14
257207702015Leigh disease due to SCO2 mutations revealed at extended autopsy.9
259596732015Cooperation between COA6 and SCO2 in COX2 maturation during cytochrome c oxidase assembly links two mitochondrial cardiomyopathies.47
263091612015The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.27

Citation

Dessen P

SCO2 (synthesis of cytochrome C oxidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46811/sco2